Results 41 to 50 of about 2,365,869 (296)

Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Zablocki, Krzysztof, Elżbieta Krasowska, Krasowska Elżbieta, Gorecki, Dariusz C., Swinny, Jerome D., Dariusz C Górecki, Swinny Jerome D., Zabłocki Krzysztof, Jerome D Swinny, Krasowska, Elzbieta, Górecki Dariusz C., Krzysztof Zabłocki   +11 more
core   +2 more sources

Synthesis of chiral pyrazolo[4,3-e][1,2,4]triazine sulfonamides with tyrosinase and urease inhibitory activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their tyrosinase and urease inhibitory activity.
Mariusz Mojzych, Paweł Tarasiuk, Katarzyna Kotwica-Mojzych, Muhammad Rafiq, Sung-Yum Seo, Michał Nicewicz, Emilia Fornal   +6 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

The influence of GABAergic signaling on dendritic processing [PDF]

, 2013
GABAergic (?-aminobutyric acid-releasing) signaling plays a crucial role in integration processes of pyramidal neurons. Specific subtypes of GABA releasing interneurons innervate different compartments of pyramidal neurons; thereby modulating the ...
Willadt, Silvia
core   +1 more source

Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18 (Continued).

, 2019
Thymidine Phosphorylase Inhibitory Activity of Compounds 1–18 (Continued).
M. Iqbal Choudhary (598049), Sumaira Javaid (7886897), Muniza Shaikh (7886900), Narjis Fatima (3778390)   +3 more
core   +3 more sources

Pancreatic lipase inhibitory activity of selected pharmaceutical agents

Acta Pharmaceutica, 2019
Twenty-five structurally diverse compounds have been tested in vitro for their pancreatic lipase (PL) inhibitory activity. Despite the diversity of tested compounds, the relationship comprising structural attributes of the compounds could be established ...
Hamdan Imad I., Kasabri Violet N., Al-Hiari Yusuf M., El-Sabawi Dina, Zalloum Hiba   +4 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
Topf, Maya, Hannan, S, Topf, M, Smart, T.G., Baker, JR, Iqbal, F, Iqbal, F., Baker, J.R., Hannan, S., Mortensen, M, Huckvale, R, Pandurangan, Arun, Pandurangan, AP, Huckvale, R., Mortensen, M., Smart, TG   +15 more
core   +1 more source

New Indole Alkaloids from the Bark of Rauvolfia Reflexa and their Cholinesterase Inhibitory Activity

Cellular Physiology and Biochemistry, 2015
Background/Aims: Rauvolfia reflexa is a member of the Apocynaceae family. Plants from the Apocynaceae family have been traditionally used in the treatment of age-related brain disorders Methods and Results: Two new indole alkaloids, rauvolfine C (1) and ...
Mehran Fadaeinasab, Alireza Basiri, Yalda Kia, Hamed Karimian, Hapipah Mohd Ali, Vikneswaran Murugaiyah   +5 more
doaj   +1 more source

Synthesis and Cap-Dependent Endonuclease Inhibition of Baloxavir Derivatives

Crystals, 2023
Baloxavir marboxil is a creative antiviral drug for influenza A and B viruses with a novel mechanism of action. In this study, three series comprising a total of 21 previously unreported target compounds were designed and synthesized.
Yiyun Wang, Jiaru Wang, Hui Wu, Longyao Cui, Zihui Meng, Zhibin Xu, Zhonghui Zheng, Jiarong Li   +7 more
doaj   +1 more source