Results 41 to 50 of about 423,721 (164)

Functionality study of chalcone-hydroxypyridinone hybrids as tyrosinase inhibitors and influence on anti-tyrosinase activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In an attempt to synthesise new tyrosinase inhibitors, we designed and synthesised a series of chalcone-hydroxypyridinone hybrids as potential tyrosinase inhibitors adopting strategic modifications of kojic acid.
L. Ravithej Singh, Yu-Lin Chen, Yuan-Yuan Xie, Wei Xia, Xing-Wen Gong, Robert C. Hider, Tao Zhou   +6 more
doaj   +1 more source

Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity

Molecules, 2018
A series of novel 2,4-diaminoquinazoline derivatives were designed, synthesized, and evaluated as p21-activated kinase 4 (PAK4) inhibitors. All compounds showed significant inhibitory activity against PAK4 (half-maximal inhibitory concentration IC50 <
Tianxiao Wu, Yu Pang, Jing Guo, Wenbo Yin, Mingyue Zhu, Chenzhou Hao, Kai Wang, Jian Wang, Dongmei Zhao, Maosheng Cheng   +9 more
doaj   +1 more source

Synthesis, biological evaluation and in silico study of 4-(benzo[d]thiazole-2-yl) phenols based on 4-hydroxy coumarin as acetylcholinesterase inhibitors

Scientific Reports
Alzheimer’s disease, characterized by cognitive decline and memory loss, is associated with decreased acetylcholine levels due to acetylcholinesterase (AChE) activity.
Bi Bi Fatemeh Mirjalili, Seyedeh Azita Fazeli Attar, Fereshteh Shiri   +2 more
doaj   +1 more source

The inhibitory effects of metabolites from Bacillus pumilus on potato virus Y and the induction of early response genes in Nicotiana tabacum

AMB Express, 2020
To develop a new antiviral preparation from a microbial source, the halophilic bacterium Bacillus pumilus E303035 was isolated from a soil sample collected at Qarhan Salt Lake in Qinghai, China.
Shuo Shen, Wei Li
doaj   +1 more source

Effective diffusion coefficients and bioconversion rates of inhibitory compounds in flocs of Saccharomyces cerevisiae

Electronic Journal of Biotechnology, 2019
Background: Fermentation strategies for bioethanol production that use flocculating Saccharomyces cerevisiae yeast need to account for the mechanism by which inhibitory compounds, generated in the hydrolysis of lignocellulosic materials, are tolerated ...
Roberto Landaeta, Fernando Acevedo, Germán Aroca   +2 more
doaj   +1 more source

Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis

Molecules, 2017
Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (3–13) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis.
Ying Wang, Hong-Xin Liu, Yu-Chan Chen, Zhang-Hua Sun, Hao-Hua Li, Sai-Ni Li, Ming-Li Yan, Wei-Min Zhang   +7 more
doaj   +1 more source

A Guideline for Assessment and Characterization of Bacterial Biofilm Formation in the Presence of Inhibitory Compounds. [PDF]

Bio Protoc, 2023
Elgamoudi BA, Korolik V.
europepmc   +1 more source

Aldose Reductase Inhibitory Compounds from Glycyrrhiza uralensis

Biological and Pharmaceutical Bulletin, 2010
We evaluated the inhibitory effects of components from the root of Glycyrrhiza uralensis (G. uralensis) on aldose reductase (AR) and sorbitol formation in rat lenses with high levels of glucose as part of our ongoing search of natural sources for therapeutic and preventive agents for diabetic complications. In order to identify the bioactive components
Lee, Yeon Sil, Kim, Seon Ha, Jung, Sang Hoon, Kim, Jin Kyu, Pan, Cheol-Ho, Lim, Soon Sung   +5 more
openaire   +3 more sources

Design, synthesis, and α-glucosidase inhibitory activity study of indole-urea derivatives

Guangxi Yike Daxue xuebao
Objective To design and synthesize novel non-sugar-based α-glucosidase inhibitors by a simple synthesis method and evaluate their inhibitory activity.
Ruiqi HUANG, Yingli DENG, Gaojie YE
doaj   +1 more source

Cancer Chemopreventive Activity of Xanthones from

Natural Product Communications, 2018
In our continuing search for compounds with antitumor-promoting activity, we screened eight xanthones isolated from Calophyllum elatum Bedd. (Guttiferae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA ...
Chihiro Ito, Takuya Matsui, Takashi Kobayashi, Harukuni Tokuda, Sivabalan Shanmugam, Masataka Itoigawa   +5 more
doaj   +1 more source