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Signal/Noise Analysis of FRET-Based Sensors [PDF]
Biophysical Journal, 2010 Molecular sensors based on intramolecular Förster resonance energy transfer (FRET) have become versatile tools to monitor regulatory molecules in living tissue. However, their use is often compromised by low signal strength and excessive noise.
Andrew Woehler +2 more
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Signal generation and storage in FRET-based nanocommunications [PDF]
Nano Communication Networks, 2019 The paper is concerned with Forster Resonance Energy Transfer (FRET) considered as a mechanism for communication between nanodevices. Two solved issues are reported in the paper, namely: signal generation and signal storage in FRET-based nanonetworks.
Krzysztof Wójcik +2 more
exaly +5 more sources
Milestones in the development and implementation of FRET-based sensors of intracellular signals: A biological perspective of the history of FRET [PDF]
Cellular Signalling, 2020 Fӧrster resonance energy transfer (FRET) has been described for more than a century. FRET has become a mainstay for the study of protein localization in living cells and tissues. It has also become widely used in the fields that comprise cellular signaling.
J, Deal +4 more
exaly +3 more sources
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Monitoring receptor signaling by intramolecular FRET
Current Opinion in Pharmacology, 2007A large variety of techniques has been used to monitor activation of G protein-coupled receptors (GPCRs) both in isolated membranes and in intact cells. However, most of these techniques cannot resolve receptor activation and signaling in space and in time.
Martin J, Lohse +4 more
openaire +2 more sources
Nano Letters, 2015 We developed a quantum-dot-based fluorescence resonance energy transfer (QD-FRET) nanosensor to visualize the activity of matrix metalloproteinase (MT1-MMP) at cell membrane.
Shaoying Lu, Andrew M Smith, Ying-Xin Qi
exaly +2 more sources
FRETting over postsynaptic PKC signaling
Nature Neuroscience, 2018Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.
Mark L. Dell’Acqua, Kevin M. Woolfrey
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FLIM-FRET of Cell Signalling in Chemotaxis
Optics in the Life Sciences, 2013We demonstrate the application of Fluorescence Lifetime Imaging (FLIM) to read out Forster resonant energy transfer (FRET) based biosensors for studying the spatio-temporal dynamics of signalling pathways in cells undergoing chemotaxis.
Sean Warren +6 more
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Automated Image Analysis of FRET Signals for Subcellular cAMP Quantification
2022A variety of FRET probes have been developed to examine cAMP localization and dynamics in single cells. These probes offer a readily accessible approach to measure localized cAMP signals. However, given the low signal-to-noise ratio of most FRET probes and the dynamic nature of the intracellular environment, there have been marked limitations in the ...
Silas J, Leavesley +4 more
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Shedding Light on Cell Signaling: Interpretation of FRET Biosensors
Science Signaling, 2003This Perspective compares recently developed approaches for studying live-cell signaling dynamics. It is now possible not only to study the changing localizations of proteins within living cells but to correlate these dynamics with quantitation of protein activities, including ligand interactions and phosphorylation.
Frédérique, Gaits, Klaus, Hahn
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SEMICONDUCTOR DEVICE FOR DETECTION OF FRET SIGNALS
2013The transducer consists on a semiconductor device based on two stacked-i-n heterostructures, that were designed to detect the emissions of the fluorescence resonance energy transfer between fluorophores in the cyan (470 nm) and yellow (588 nm) range of the spectrum.
Louro, Paula +4 more
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