Results 201 to 210 of about 62,035 (345)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Faults of Contacts in PV Module Junction Boxes due to Fretting Corrosion

open access: green, 2014
K.-M. Jakobi   +5 more
openalex   +1 more source

Recent Advances in Enhancing the Stability of CsPbI3 Perovskite Quantum Dots for Light‐Emitting Diodes

open access: yesRare Metals, EarlyView.
ABSTRACT CsPbI3 quantum dots (QDs) have attracted considerable attention as promising candidates for light‐emitting diode (LED) applications. However, their intrinsic tendency to undergo a spontaneous phase transition to a nonperovskite structure significantly hampers their practical deployment. Considerable efforts have been devoted to stabilizing the
Yajing Chang   +12 more
wiley   +1 more source

FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor [PDF]

open access: bronze, 2017
Nathalie Lecat-Guillet   +8 more
openalex   +1 more source

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome

open access: yesSmall, EarlyView.
Biomimetic nanocarriers based on liposomes and Myxobacteria outer‐membrane vesicles (OMVs) are effective antibiotic delivery systems. Hybrids have a higher drug loading and can target intracellular pathogens, while OMVs evade immune clearance. Biomimetic nanoantibiotics effectively eliminate the biofilms of Gram‐negative bacteria. Besides, Myxobacteria
Leila Pourtalebi Jahromi   +13 more
wiley   +1 more source

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