Results 41 to 50 of about 29,317 (303)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Design of a fretting fatigue test rig with compliant springs [PDF]

, 2013
Fretting is a small amplitude oscillatory movement which occurs between contacting bodies who are subjected to cyclic loading or vibrations. In the contact area arise stresses -normal and tangential- causing stress concentrations and surface degradation.
De Baets, Patrick, De Pauw, Jan, De Waele, Wim, Hojjati Talemi, Reza   +3 more
core  

Finite element analysis of fretting crack propagation

, 2011
In this work, the finite elements method (FEM) is used to analyse the growth of fretting cracks. FEM can be favourably used to extract the stress intensity factors in mixed mode, a typical situation for cracks growing in the vicinity of a fretting ...
Basseville, Stéphanie, Proudhon, Henry
core   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Dynamic evolution of interface roughness during friction and wear processes [PDF]

, 2014
Dynamic evolution of surface roughness and influence of initial roughness (Sa=0.282 to 6.73 µm) during friction and wear processes has been analyzed experimentally.
Bigerelle, Bigerelle, Bouchbinder, Brown, Elliott, Fu, Jerier, Kang, Kasarekar, Kubiak, Kubiak, Kubiak, Kubiak, Kubiak, Rapiejko, Scott, Sokoloff, Stahlmann, Ungar   +18 more
core   +4 more sources

Evaluation of the Potential of Laser Shock Peening Compared with Cold Expansion for Improving Fatigue Resistance of Riveted Lap Joints of Aerospace Grade 7175 Al Alloy

Advanced Engineering Materials, EarlyView.
This study investigates laser shock peening for enhancing fatigue performance of riveted aerospace aluminum joints. A comparative approach with cold expansion combines fatigue testing and synchrotron X‐ray methods. Integrating mechanical testing with residual stress and strain characterization provides insights into how different treatments affect the ...
Ogün Baris Tapar, David Osman Busse, Maximilian Sprengel, Domenico Furfari, Marc‐André Nielsen, Guilherme Abreu Faria, Jérémy Epp   +6 more
wiley   +1 more source

FRET and mechanobiology [PDF]

Integrative Biology, 2009
Since the development of green fluorescent protein (GFP) and other fluorescent proteins (FPs) with distinct colors, genetically-encoded probes and biosensors have been widely applied to visualize the molecular localization and activities in live cells.
Yingxiao, Wang, Ning, Wang
openaire   +2 more sources

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Effect of Ultrasonic Surface Rolling on the Fretting Wear Property of 7075 Aluminum Alloy

Metals, 2023
This paper investigates the effect of ultrasonic surface rolling (USR) on the fretting wear properties of the 7075 aluminum alloy. A white light interferometer, Vickers hardness tester, and X-ray diffractometer were employed to comparatively analyze the ...
Qiwen Xiong, Po Zhang, Wenzheng Zhai, Xiaoshuang Luo, Zhaobing Cai, Feilong Zheng, Le Gu   +6 more
doaj   +1 more source

Fretting Corrosion Behavior of Additive Manufactured and Cryogenic-Machined Ti6Al4V for Biomedical Applications [PDF]

, 2016
Metal ion release, caused by synergistic effect of wear and corrosion, is one of the major concerns related to the prostheses lifetime. In this work, samples of additive manufactured Ti6Al4V are machined under dry cutting and cryogenic cooling conditions
Alam, Baxmann, Bermingham, Bordin, Bordin, Chen, Cook, Cook, Diomidis, Doni, Dyrkacz, Froes, García-Alonso, Gil, Gilbert, Higgs, Hussenbocus, Kawalec, Li, Long, Noyan, Pu, Pusavec, Rituerto, Roy, Royhman, Sartori, Sinnett-Jones, Takakuwa, Tobi, Urban, Vidal, Vingsbo, Wan, Zhang   +34 more
core   +1 more source