Results 51 to 60 of about 1,057,920 (276)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

INDENTATION OF FLAT-ENDED AND TAPERED INDENTERS WITH POLYGONAL CROSS-SECTIONS

Facta Universitatis. Series: Mechanical Engineering, 2016
Using the Boundary Element Method, we numerically study the indentation of prismatic and tapered indenters with polygonal cross-sections. The contact stiffness of punches with flat bases in the form of a triangle and a square as well as a number of ...
Qiang Li, Valentin L. Popov
doaj   +1 more source

Microstructure and mechanical properties of diffusion bonded joints of high-entropy alloy Al5(HfNbTiZr)95 and TC4 titanium alloy

Journal of Materials Research and Technology, 2021
TC4 (Ti–6Al–4V) titanium alloy and Al5(HfNbTiZr)95 refractory high-entropy alloy were successfully diffusion bonded at a temperature range of 800–1000 °C for 60 min under 5 MPa.
Yu Peng, Jinglong Li, Junmiao Shi, Shiwei Li, Jiangtao Xiong   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Velocity dependence of joint friction in robotic manipulators with gear transmissions [PDF]

, 2005
This paper analyses the problem of modelling joint friction in robotic manipulators with gear transmissions at joint velocities varying from close to zero until their maximum appearing values.
Aarts, Ronald, Jonker, Ben, Waiboer, Rob
core   +2 more sources

Coarse-grained model for spring friction study of micron-scale iron by smoothed particle hydrodynamics

, 2018
The paper constructs a coarse-grained model to investigate dry sliding friction of the body-centered-cubic Fe micron-scale system by smoothed particle hydrodynamics simulations and examines influences of the spring force on the characters of friction ...
Fujii, Shuji, Sugimura, Natsuko, Van Sang, Le, Washizu, Hitoshi, Yano, Akihiko   +4 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Adsorbate vibrational modes enhancement of radiative heat transfer and van der Waals friction

, 2006
We study the dependence of the heat transfer and the van der Waals friction between two semi-infinite solids on the dielectric properties of the bodies. We show that the heat transfer and van der Waals friction at short separation between the solids may ...
A.I. Volokitin, B.N.J. Persson, Dedkov, Dorofeyev, Dzyaloshinskii, Fuchs, Gostmann, Gramila, Gramila, Greffet, Hartmann, Hoffmann, Johansson, Kliever, Kyasov, Landau, Levin, Levitov, Lifshitz, Majumdar, Mamin, Mkrtchian, Mulet, Palik, Pendry, Pendry, Persson, Polder, Polevoi, Schaich, Senet, Sivan, Stipe, Theodorovitch, Tomassone, Volokitin, Volokitin, Volokitin, Volokitin, Volokitin, Volokitin, Volokitin, Volokitin, Zurita-Sánchez   +43 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dependence of kinetic friction on velocity: Master equation approach [PDF]

, 2011
We investigate the velocity dependence of kinetic friction with a model which makes minimal assumptions on the actual mechanism of friction so that it can be applied at many scales provided the system involves multi-contact friction.
Braun, Oleg, Peyrard, Michel
core   +4 more sources