Results 51 to 60 of about 489,397 (293)
Journal of Materials Research and Technology, 2021 The precipitation behavior and development of grain structure have been investigated to reveal their association with the microhardness and corrosion resistance of probeless friction stir spot welded (P-FSSW) joint of an Al–Li alloy.
Q. Chu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
TIG Wire and Arc Additive Manufacturing of 5A06 Aluminum Alloy
Cailiao gongcheng, 2017 Wire and arc additive manufacturing(WAAM) was investigated by tungsten inert gas arc welding method(TIG), in which φ1.2mm filler wire of aluminum alloy 5A06(Al-6Mg-Mn-Si) was selected as deposition metal.
HUANG Dan +5 more
doaj +1 more source
SSRN Electronic Journal, 2013 The world is replete with spatial frictions. Shipping goods across cities entails trade frictions. Commuting within cities causes urban frictions. How important are these frictions in shaping the spatial economy? We develop and quantify a multi-city general equilibrium model to address this question at three different levels: Do spatial frictions ...
Behrens, Kristian +3 more
openaire +7 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Influence of Chemical Heterogeneity and Third Body on Adhesive Strength: Experiment and Simulation
Frontiers in Mechanical Engineering, 2021 We investigate experimentally and numerically the influence of chemical heterogeneity and of third-body particles on adhesive contact. Chemical heterogeneity is generated by chemical treatment of the contacting bodies changing locally the surface energy.
Iakov A. Lyashenko +4 more
doaj +1 more source
A comparison of double sided friction stir welding in air and underwater for 6mm S275 steel plate [PDF]
, 2014 This study compared the mechanical and microstructural properties produced during friction stir welding (FSW) of S275 structural steel in air and underwater.
Baillie, Philip +9 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Shock isolation systems incorporating Coulomb friction
, 2012 This study investigates a novel approach to the problem of shock isolation. The questions considered are whether friction produces a better performance in terms of reduced response during a shock compared to viscous damping and a lower residual response ...
Ismail, Mohd
core +1 more source
Journal of Materials Research and Technology, 2020 Nickel-based single crystal superalloy DD6 was diffusion bonded in vacuum at 1170 °C under 55 MPa for 2–6 h. Two processes, direct bonding and bonding with interlayer, were designed for comparison.
Yu Peng +5 more
doaj +1 more source