Results 51 to 60 of about 4,037,251 (243)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Running-In Behavior and Failure Mechanism Between AgCuNi Alloy and Au-Electroplated Layer
SensorsTo avoid wear and tear of the slip ring due to electrical corrosion, the slip ring needs to undergo the running-in process under atmospheric conditions without current after assembly.
Hongjian Wu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Experimental characterization of friction coefficients at the tool-chip-workpiece interface in cutting: Evaluation of lubrication efficiency of mineral oil [PDF]
, 2010 Collaboration avec le LTDS/ENISEThe characterization of friction coefficients at the tool-chip-workpiece interface remains an issue. This paper presents a new experimental set-up able to simulate similar tribological phenomena as the ones occurring at ...
RECH, Joël +4 more
core
Materials Research LettersAg coatings by additive manufacturing are a representative high-performance electrical contact materials. Here, an appropriate current of 2 A is introduced during the friction process to optimize the current-carrying friction behavior and anti-wear ...
Jiebin Du +4 more
doaj +1 more source
Friction hysteretic behavior of supported atomically thin nanofilms
npj 2D Materials and Applications, 2023 Hysteretic friction behavior has been observed on varied 2D nanofilms. However, no unanimous conclusion has yet been drawn on to the exact mechanism or relative contribution of each mechanism to the observed behavior.
Chaochen Xu, Zhijiang Ye, Philip Egberts
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Qualification of a robotized Friction Stir Welding System [PDF]
, 2010 This paper presents an experimental methodology to determine a Friction Stir Welding (FSW) means of production based on the experimental study of the tool / material mechanical interactions generated during the welding operation.
MARTIN, Patrick +5 more
core
Numerical Model for Hydration-Lubricated Contact and Its Friction Behavior at Nanoscale
Frontiers in Mechanical Engineering, 2020 In this study, we propose a numerical model to investigate the contact and friction behaviors of hydration-lubricated contact in an aqueous solution confined in a gap of several molecular diameters.
Yanfei Fang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source