Results 21 to 30 of about 66,420 (262)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Experimental study of solar air heater with C-shaped ribs coated with zeolite [PDF]
Chemical Industry and Chemical Engineering QuarterlyA study was conducted to determine the heat transmission rate and friction properties of a solar air heater's (SAH) absorber by including a c-shaped rib, with and without perforations, and the efficiency of this absorber with and without zeolite coating ...
Petchimuthu Sureshkumar +1 more
doaj +1 more source
FRICTIONAL ELECTRICITY : A FACTOR IN CAISSON DISEASE. [PDF]
The Lancet, 1906 n ...
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
RESEARCH OF ADAPTIVE FRICTION CLUTCH WITH DIFFERENTIATED FRICTION PAIRS
Вестник Донского государственного технического университета, 2018 The problem of the clutch operation accuracy increase without introducing material changes into its construction is solved on the ground of N.D. Verner's construction of the adaptive lamellar clutch which friction group consists of disks made from the ...
Alexander E. Fokin +2 more
doaj
Turbulence Intensity Scaling: A Fugue
Fluids, 2019 We study streamwise turbulence intensity definitions using smooth- and rough-wall pipe flow measurements made in the Princeton Superpipe. Scaling of turbulence intensity with the bulk (and friction) Reynolds number is provided for the definitions.
Nils T. Basse
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source