Results 21 to 30 of about 65,934 (262)

Experimental study of solar air heater with C-shaped ribs coated with zeolite [PDF]

open access: yesChemical Industry and Chemical Engineering Quarterly
A study was conducted to determine the heat transmission rate and friction properties of a solar air heater's (SAH) absorber by including a c-shaped rib, with and without perforations, and the efficiency of this absorber with and without zeolite coating ...
Petchimuthu Sureshkumar   +1 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Turbulence Intensity Scaling: A Fugue

open access: yesFluids, 2019
We study streamwise turbulence intensity definitions using smooth- and rough-wall pipe flow measurements made in the Princeton Superpipe. Scaling of turbulence intensity with the bulk (and friction) Reynolds number is provided for the definitions.
Nils T. Basse
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

RESEARCH OF ADAPTIVE FRICTION CLUTCH WITH DIFFERENTIATED FRICTION PAIRS

open access: yesВестник Донского государственного технического университета, 2018
The problem of the clutch operation accuracy increase without introducing material changes into its construction is solved on the ground of N.D. Verner's construction of the adaptive lamellar clutch which friction group consists of disks made from the ...
Alexander E. Fokin   +2 more
doaj  

An analytical approach for predicting the fillet and contact stresses in symmetric and asymmetric spur gears under frictional mesh assumptions

open access: yesResults in Engineering
A precise estimation of the bending and contact stresses, as well as the true friction value during the gear mesh, are critical aspects of a cost-effective and safe gear design.
Ahmed A. Toman, Mohammad Q. Abdullah
doaj   +1 more source

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