Results 41 to 50 of about 76,686 (264)

Study on the Influence of Excavation Unloading on Pile Depth in Sandy Soil

Geofluids, 2022
With the development of urban construction, uplift pile has been widely used in underground structure bearing buoyancy. The pile is buried deep underground, and the foundation pit is excavated on the pile foundation, the stress redistribution of the soil
Huang Zhanjun, Zou Yi, Ding Haibin, Liang Xinhuan, Zhu Bitang, Jiang Yalong   +5 more
doaj   +1 more source

Calculation Method of the Finite Soil Pressure for a New Foundation Pit Adjacent to an Existing Subway Station

Applied Sciences, 2023
The study aimed at the simple prediction problem of finite soil pressure for a new foundation pit adjacent to an existing subway station. Failure modes of the finite soil were proposed.
Zhenbo Zhang, Jiadi Zhou, Fei Xu, Zhichun Liu, Minglei Sun   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Effect of Time-varying Friction Factors on the Contact Fatigue Life of Gears

Jixie chuandong, 2023
The tooth surface friction has an important impact on the tooth surface contact stress and the tooth surface contact fatigue life. In the estimation of the contact fatigue life of the tooth surface, the influence of the friction force of the tooth ...
Li Xuefei, Li Jiqiang, Chen Zhuo, Li Zhiyuan, Shi Lubing, Liu Zhongming   +5 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Influence of surface topography on three-dimensional fractal model of sliding friction

AIP Advances, 2017
The purpose of this paper is to establish a three-dimensional model of sliding friction and to study the influence of surface topography fractal parameters on the model.
Wujiu Pan, Xiaopeng Li, Linlin Wang, Jiaxin Mu, Zemin Yang   +4 more
doaj   +1 more source

Influence of Friction Stir Processing Parameters on the Mechanical and Corrosion Properties of Al-Cu-Li Alloy [PDF]

Iranian Journal of Materials Science and Engineering, 2023
Novelty: Most of the open literature research has focused on the microstructural evolution and mechanical properties of AA2050 alloy. Also, a significant study discusses the corrosion behavior of AA2050 alloy based on immersion and electrochemical ...
Sandeep Ramasamy Periasamy, Vaira Vignesh Ramalingam, Ajay Vijayakumar, HarieHarran Senthilkumaran, VyomaTeja Sajja, Padmanaban Ramasamy, Samuel Ratna Kumar Kumar Paul Sureshkumar   +6 more
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source