Results 21 to 30 of about 930,149 (308)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego +10 more
wiley +1 more source
The Religious Factor in the North Caucasian Frontier Zone
Журнал Фронтирных ИсследованийWhile religious factor played a significant role in the history of the North Caucasian frontier, it was not a primary institution. Despite increased scholarly attention to the frontier dynamics of this region over the past two decades, the influence of ...
Sharafutdin A. Magaramov
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mobility and tourist locations. The case of Martinique Island, a French territory in the Caribbean
Belgeo, 2005 This paper contributes to the analysis of the mobility system through strategic sites represented by tourist locations, mirrors of globalisation. Tourist locations exist merely through human flows: varied and complex flows between migrations and tourism.
Olivier Dehoorne, Huhua Cao
doaj +1 more source
Enabling scalability by partitioning virtual environments using frontier sets [PDF]
, 2006 We present a class of partitioning scheme that we have called frontier sets. Frontier sets build on the notion of a potentially visible set (PVS). In a PVS, a world is subdivided into cells and for each cell all the other cells that can be seen are ...
Angus, C., Steed, A.
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
The Virtualization of the Sociocultural Frontier “Tertius Romae.” Translation from Russian
Журнал Фронтирных ИсследованийThe article addresses the need to clarify the semantic core of the sociocultural frontier Tertius Romae. The theoretical construct of Tertius Romae, originating in the writings of Marcus Tullius Cicero, has undergone significant semantic transformations ...
Gennady V. Bakumenko, Anna G. Luginina
doaj +1 more source
Caravelle, 2019 Spanish Louisiana (1763-1803), including both eastern and western Floridas after 1783, is an exemplary cultural mosaic at the crossroads of empires.
Soizic Croguennec
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Rechtsgeschichte - Legal History, 2023 This article reviews ecclesiastical opinions on Indigenous slavery in early modern Chile, the southernmost frontier of the Spanish Empire. Generally, historiography has only analyzed missionary relations with the Mapuche people on the Mapuche-Hispanic ...
Constanza López Lamerain
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source