Results 41 to 50 of about 162,375 (268)

The Virtualization of the Sociocultural Frontier “Tertius Romae.” Translation from Russian

open access: yesЖурнал Фронтирных Исследований
The article addresses the need to clarify the semantic core of the sociocultural frontier Tertius Romae. The theoretical construct of Tertius Romae, originating in the writings of Marcus Tullius Cicero, has undergone significant semantic transformations ...
Gennady V. Bakumenko, Anna G. Luginina
doaj   +1 more source

Rendre la justice en Louisiane espagnole (1763-1803) : aménagements, improvisations et instrumentalisations

open access: yesCaravelle, 2019
Spanish Louisiana (1763-1803), including both eastern and western Floridas after 1783, is an exemplary cultural mosaic at the crossroads of empires.
Soizic Croguennec
doaj   +1 more source

Ecclesiastics and Indigenous Slavery on the Frontier: The Case of Chile in the 16th and 17th Centuries

open access: yesRechtsgeschichte - Legal History, 2023
This article reviews ecclesiastical opinions on Indigenous slavery in early modern Chile, the southernmost frontier of the Spanish Empire. Generally, historiography has only analyzed missionary relations with the Mapuche people on the Mapuche-Hispanic ...
Constanza López Lamerain
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The Problem of Ethnic Identification of the Yurt Tatars. Translation from Russian

open access: yesЖурнал Фронтирных Исследований
In contemporary historiography, the question of the ethnogenesis of the Yurt Tatars on the Astrakhan frontier remains particularly relevant. Various scholars and local historians, drawing on extensive archival sources and accounts by travellers and ...
Rastyam T. Aliev
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

“Urban by nature”: The Sokoto jihadist approach to urban planning

open access: yesAfriques, 2020
Like other Islamic reform and state-building movements across the pre-colonial Sahel, the Sokoto Jihad of 1804 had started genuine urbanization processes with architectural references to Islamic ideals of inhabited space.
Stephanie Zehnle
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan   +14 more
wiley   +1 more source

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