Results 41 to 50 of about 163,275 (268)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Limes of Civilization in the Novel Cold Skin by Albert Sánchez Piñol

open access: yesCastilla: Estudios de Literatura, 2014
The novel Cold Skin by Albert Sánchez Piñol is configured as a novel space around the border between civilization and barbarism, the boundary between Numano and otherness.
Rodrigo Pardo Fernández
doaj   +2 more sources

Pursuing the Zionist Dream on the Palestinian Frontier

open access: yesActa Neophilologica, 2020
This paper critically examines Theodore Herzl’s canonical Zionist novel, Altneuland /Old New Land as a frontier narrative which depicts the process of Jewish immigration to Palestine as an inevitable historical process aiming to rescue European Jews ...
Saddik Mohamed Gohar
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Eric Ambler and the Trick of Boundaries

open access: yesAltre Modernità, 2018
One of the dominant themes of Eric Ambler's novels of the 1930s is certainly the crossing of frontiers as both a physical and symbolic element, which results not only in the living of a nightmarish adventure but also in what spy fiction expert Michael ...
Nadia Priotti
doaj   +1 more source

Frontiers of conservation

open access: yesConservation Biology
Abstract Action‐oriented conservation sciences are crippled by 3 false assumptions. First, although it is recognized in theory that natural and anthropic components of ecosystems are tightly intertwined, in practice, many conservation policies and actions are still based on the assumption that human and nonhuman ...
Meinard, Yves, Georges, Jean-Yves
openaire   +5 more sources

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan   +14 more
wiley   +1 more source

THE EASTERN FRONTIER OF THE EUROPEAN UNION. EXPRESSION OF THE PAST / FUTURE BINOME [PDF]

open access: yesAnnals: Series on History and Archaeology (Academy of Romanian Scientists), 2015
The Study enounces first of all, the fundamental no tions of international law concerning the frontier as limit of the State territory and of the exercise of sovereignty on this space. Then, it presents the evolution of
Ion M. ANGHEL
doaj  

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig   +9 more
wiley   +1 more source

Frontiers in Bioethics [PDF]

open access: yesThe American Journal of Bioethics, 2020
Last year a bioethics colleague from another institution was expressing her frustration and doubts about the direction of the field of bioethics to me.
openaire   +2 more sources

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