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A case of familial frontotemporal dementia caused by a progranulin gene mutation
Clinical Parkinsonism & Related Disorders, 2023 After Alzheimer’s disease, Frontotemporal dementia (FTD) is the most common cause of early-onset dementia. Several genetic mutations have been identified in familial FTD, with mutations in progranulin (GRN) accounting for approximately 20–25% of familial
Lauryn Currens +7 more
doaj +1 more source
Phenocopy syndrome of frontotemporal dementia
European Psychiatry, 2021 Introduction Frontotemporal dementia (FTD) is a group of neurodegenerative disorders characterized by behavioral or language changes with progressive executive dysfunction. It´s subdivided into two variants, the behavioral and language variants.
D. Martins +3 more
doaj +1 more source
Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]
, 2019 Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F +22 more
core +3 more sources
Neurologic Clinics, 2016 Frontotemporal dementia (FTD) is a not-uncommon explanation for progressive cognitive deficit in patients who often have a genetic susceptibility for such a neurodegenerative process. However, FTD does not seem to identify one particular pathogenetic mechanism but rather a spectrum of pathologies with particular predilection for the frontal and ...
Roger E, Kelley, Ramy, El-Khoury
openaire +2 more sources
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018 Introduction Apraxia is common in neurodegenerative dementias but underrepresented in clinical workup for differential diagnoses. Methods Praxis‐profiles were assessed with the Dementia Apraxia Test in 93 patients with early stages of biologically ...
Andreas Johnen +4 more
doaj +1 more source
Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias [PDF]
, 2010 Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25 ...
Bibl, Mirko +8 more
core +1 more source
Evaluation of the INECO Frontal Screening and the Frontal Assessment Battery in Peruvian patients with Alzheimer's disease and behavioral variant Frontotemporal dementia [PDF]
, 2016 Background: The physicians often confuse the early symptoms of Frontotemporal dementia (FTD) with Alzheimer dementia (AD), leading to misdiagnosis. There are some cognitive tests to discriminate between AD and behavioral variant FTD (bvFTD), and the ...
Báez Buitrago, Sandra Jimena +6 more
core +2 more sources
The C9ORF72 mutation brings more answers and more questions. [PDF]
, 2013 The clinical, neuropsychiatric and neuroimaging features of patients who carry the important new C9ORF72 mutation are discussed in this special series of Alzheimer's Research & Therapy.
Miller, Bruce L
core +1 more source
Frontotemporal Dementias [PDF]
Continuum, 2016 This article reviews the common behavioral and cognitive features of frontotemporal dementia (FTD) and related disorders as well as the distinguishing clinical, genetic, and pathologic features of the most common subtypes.Advances in clinical phenotyping, genetics, and biomarkers have enabled improved predictions of the specific underlying molecular ...
openaire +2 more sources
Frontotemporal Dementias: A Review [PDF]
Annals of General Psychiatry, 2007 Abstract Dementia is a clinical state characterized by loss of function in multiple cognitive domains. It is a costly disease in terms of both personal suffering and economic loss. Frontotemporal dementia (FTD) is the term now preferred over Picks disease to describe the spectrum of non-Alzheimers dementias characterized by focal atrophy of ...
Rehan Aziz +3 more
openaire +4 more sources