Results 41 to 50 of about 368,079 (211)

The C9ORF72 mutation brings more answers and more questions. [PDF]

, 2013
The clinical, neuropsychiatric and neuroimaging features of patients who carry the important new C9ORF72 mutation are discussed in this special series of Alzheimer's Research & Therapy.
Miller, Bruce L
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Physiological, behavioral and subjective sadness reactivity in frontotemporal dementia subtypes. [PDF]

, 2019
Frontotemporal dementia (FTD), a neurodegenerative disease broadly characterized by socioemotional impairments, includes three clinical subtypes: behavioral variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non-fluent variant ...
Brown, Casey L, Casey, James J, Chen, Kuan-Hua, Hua, Alice Y, Levenson, Robert W, Lwi, Sandy J, Miller, Bruce L, Rosen, Howard J   +7 more
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Characterizing sexual behavior in frontotemporal dementia [PDF]

, 2015
Background: Frontotemporal dementia (FTD) is characterized by a number of prominent behavioral changes. While FTD has been associated with the presence of aberrant or unusual sexual behaviors in a proportion of patients, few studies have formally ...
Ahmed, Rebekah M., Dermody, Nadene, Hodges, John R., Irish, Muireann, Kaizik, Cassandra, Kiernan, Matthew C., Mioshi, Eneida, Piguet, Olivier   +7 more
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Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. [PDF]

, 2019
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Arrant, Andrew E, Boyle, Nicholas R, Grinberg, Lea T, Hoffmann, Madelyn Q, Kashyap, Shreya N, Miller, Bruce L, Murchison, Charles F, Nana, Alissa L, Ramos, Eliana Marisa, Roberson, Erik D, Roth, Jonathan R, Seeley, William W, Spina, Salvatore   +12 more
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Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. [PDF]

, 2019
Tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia (FTD). Early and selective loss of von Economo neurons (VENs) and fork cells within the frontoinsular (FI) and anterior cingulate cortices (ACC) is observed in ...
Coppola, Giovanni, Cosme, Celica G, Gan, Li, Gaus, Stephanie E, Geschwind, Daniel H, Grinberg, Lea T, Hepker, Mackenzie, Hwang, Ji-Hye Lee, Lin, Li-Chun, Miller, Bruce L, Nana, Alissa L, Rosen, Howard J, Seeley, William W, Spina, Salvatore   +13 more
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Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia [PDF]

, 2016
Background and Purpose: This study investigated the structural and functional changes in the motor system in amyotrophic lateral sclerosis (ALS; n=25) and behavioral-variant fronto-temporal dementia (bvFTD; n=17) relative to healthy controls (n=37 ...
Bae, Jong Seok, Burrell, James, Ferguson, Michele, Hodges, John R., Hornberger, Michael, Kiernan, Matthew C., Mioshi, Eneida, Simon, Neil, Tan, Rachel, Vucic, Steve   +9 more
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18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

Alzheimer's Research & Therapy, 2019
The tau positron emission tomography (PET) ligand 18F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer’s disease (AD), but its utility in detecting tau aggregates in frontotemporal dementia (FTD) is uncertain. We performed 18F-
Richard M. Tsai, Alexandre Bejanin, O. Lesman-Segev, Renaud LaJoie, Adrienne V Visani, Viktoriya Bourakova, J. O’Neil, M. Janabi, S. Baker, Suzee E Lee, D. Perry, Lynn P. Bajorek, A. Karydas, S. Spina, L. Grinberg, W. Seeley, E. Ramos, G. Coppola, M. Gorno-Tempini, B. Miller, H. Rosen, W. Jagust, A. Boxer, G. Rabinovici   +23 more
semanticscholar   +1 more source

A comparison of magnetic resonance imaging and neuropsychological examination in the diagnostic distinction of Alzheimer’s disease and behavioral variant frontotemporal dementia [PDF]

, 2016
The clinical distinction between Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) remains challenging and largely dependent on the experience of the clinician.
Andersson, Baddeley, Bertoux, Bertoux, Burgess, Cohen, Cuingnet, De Souza, Dubois, Ekman, Good, Gorno-Tempini, Hamelin, Hinrichs, Hornberger, Hornberger, Hornberger, Hornberger, Jingjing Wang, John R. Hodges, Klöppel, Liu, Maxime Bertoux, Michael Hornberger, Mioshi, Mioshi, Perry, Possin, Rascovsky, Reitan, Rey, Rey, Rueckert, Seeley, Shi, Smith, Stephen J. Redmond, Walhovd, Wedderburn, Whitwell, Zhang, Zhang, Zhang, Zhou   +43 more
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Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials

Brain : a journal of neurology, 2019
Frontotemporal dementia refers to a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or TDP-43 proteins.
A. Staffaroni, P. Ljubenkov, J. Kornak, Y. Cobigo, Samir Datta, G. Marx, Samantha M. Walters, Kevin Chiang, Nicholas T Olney, F. Elahi, D. Knopman, B. Dickerson, B. Boeve, M. Gorno-Tempini, S. Spina, L. Grinberg, W. Seeley, B. Miller, J. Kramer, A. Boxer, H. Rosen   +20 more
semanticscholar   +1 more source

Validation of the German Revised Addenbrooke's Cognitive Examination for Detecting Mild Cognitive Impairment, Mild Dementia in Alzheimer's Disease and Frontotemporal Lobar Degeneration [PDF]

, 2010
Background/Aims: The diagnostic accuracy of the German version of the revised Addenbrooke's Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI), mild dementia in Alzheimer's disease (AD) and mild dementia in frontotemporal lobar ...
Aguilar, C. A., Alexopoulos, P., Danek, Adrian, Diehl-Schmid, J., Ebert, A., Foerstl, H., Gourzis, P., Kneib, T., Kornhuber, J., Kurz, A., Natale, B., Perneczky, R., Richter-Schmidinger, T., Schoell, E., Weih, M.   +14 more
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