Results 101 to 110 of about 24,976 (233)

Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum ...
Hélène Pouclet‐Courtemanche, Tri‐Bao Nguyen, Emilie Skrobala, Claire Boutoleau‐Bretonnière, Florence Pasquier, Elodie Bouaziz‐Amar, Edith Bigot‐Corbel, Susanna Schraen, Julien Dumurgier, Claire Paquet, Thibaud Lebouvier   +10 more
doaj   +1 more source

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Al-Sarraj, Safa, Alafuzoff, Irina, Arzberger, Thomas, Bogdanovic, Nenad, Budka, Herbert, Capellari, Sabina, Ferrer, Isidro, Gelpi, Ellen, Kovacs, Gabor G., Kovari, Viktor, Kretzschmar, Hans, Nagy, Zoltan, Parchi, Piero, Seilhean, Danielle, Soininen, Hilkka, Troakes, Claire   +15 more
core   +1 more source

[¹⁸F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration [PDF]

, 2023
Ganna Blazhenets, David N. Soleimani‐Meigooni, Wesley P. Thomas, Nidhi S. Mundada, Matthias Brendel, Stephanie Vento, Lawren VandeVrede, Hilary W. Heuer, Peter A. Ljubenkov, Julio C. Rojas, Miranda Chen, Alinda Amuiri, Zachary Miller, Maria Luisa Gorno‐Tempini, Bruce L. Miller, Howie Rosen, Irene Litvan, Murray Grossman, Bradley F. Boeve, Alexander Pantelyat, Maria Carmela Tartaglia, David J. Irwin, Brad C. Dickerson, Suzanne L. Baker, Adam L. Boxer, Gil D. Rabinovici, Renaud La Joie   +26 more
openalex   +1 more source

A complex network perspective on brain disease

Biological Reviews, Volume 101, Issue 1, Page 364-399, February 2026.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration [PDF]

, 2014
Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort
Alexopoulos, Panagiotis, Almeida, Maria Rosário, Archetti, Silvana, Bagnoli, Silvia, Benussi, Luisa, Binetti, Giuliano, Boada, Mercè, Bonvicini, Cristian, Borroni, Barbara, Chiang, Huei-Hsin, Clarimón, Jordi, Cras, Patrick, Cruts, Marc, De Deyn, Peter Paul, De Jonghe, Peter, De Mendonça, Alexandre, Dermaut, Bart, Deschamps, William, Diehl-Schmid, Janine, Dillen, Lubina, Dols Icardo, Oriol, Engelborghs, Sebastiaan, Fabrizi, Gian Maria, Frisoni, Giovanni B., Gelpi, Ellen, Ghidoni, Roberta, Graff, Caroline, Haack, Tobias B., Heneka, Michael, Hernández, Isabel, Jessen, Frank, Jordanova, Albena, Kovacs, Gabor G., Laureys, Annelies, Llado Plarrumani, Albert, Lleó, Alberto, Maetzler, Walter, Martin, Jean-Jacques, Matej, Radoslav, Mattheijssens, Maria, Merlin, Celine, Miltenberger-Miltényi, Gabriel, Nacmias, Benedetta, Ortega-Cubero, Sara, Padovani, Alessandro, Parobkova, Eva, Pastor, Pau, Peeters, Karin, Perneczky, Robert, Prokisch, Holger, Ramirez, Alfredo, Razquin, Cristina, Robberecht, Wim, Ruiz Laza, Agustín, Salmon, Eric, Sanchez-Valle, Raquel, Santana, Isabel, Santens, Patrick, Santiago, Beatriz, Sarafov, Stayko, Schöls, Ludger, Sieben, Anne, Simões do Couto, Frederico, Sleegers, Kristel, Smets, Katrien, Sorbi, Sandro, Strom, Tim M., Ströbel, Thomas, Synofzik, Matthis, Testi, Silvia, Thonberg, Hakan, Tournev, Ivailo, Universitat Autònoma de Barcelona. Departament de Medicina, Van Broeckhoven, Christine, Van Damme, Philip, Van Den Broeck, Marleen, Van der Zee, Julie, Van Langenhove, Tim, Vandenberghe, Rik, Vandenbulcke, Mathieu, Vom Hagen, Jennifer Müller   +80 more
core   +4 more sources

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP‐43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

Neuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón, Cristina Benito‐Casado, Carmen María Fernández‐Martos, María José Polanco Mora   +3 more
wiley   +1 more source

Terra incognita—cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia [PDF]

, 2015
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a
Emma eDevenney, Emma eDevenney, Glenda M Halliday, Glenda M Halliday, John R Hodges, John R Hodges, John R Hodges, Matthew C Kiernan, Matthew C Kiernan, Michael eHornberger, Michael eHornberger, Michael eHornberger, Rachel H Tan, Rachel H Tan   +13 more
core   +2 more sources

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir, Giada Giorgini, Irene Santos‐García, Elizabeth Dumais, Carmen Rodríguez‐Cueto, Eva de Lago, Cristoforo Silvestri, Nicolas Flamand, Javier Fernández‐Ruiz, Vincenzo Di Marzo   +9 more
wiley   +1 more source

Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review

Arquivos de Neuro-Psiquiatria
Objectives: To explore the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD), as the patterns of symptoms and cognitive performance that characterize both disorders share similarities.
Leandro Boson Gambogi, Henrique Cerqueira Guimarães, Leonardo Cruz De Souza, Paulo Caramelli   +3 more
doaj   +1 more source

Phenotypic heterogeneity of monogenic frontotemporal dementia

Frontiers in Aging Neuroscience, 2015
Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder characterized by personality changes, language impairment and deficits of executive functions associated with frontal and temporal lobe degeneration.
Alberto eBenussi, Alessandro ePadovani, Barbara eBorroni   +2 more
doaj   +1 more source