Results 101 to 110 of about 30,886 (249)

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations [PDF]

, 2017
Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions in neurons and glial cells is the pathological hallmark of all patients with amyotrophic lateral sclerosis with mutations in FUS as well as in several subtypes of ...
Ang, Lee-Cyn, Ansorge, Olaf, Bentmann, Eva, Bilbao, Juan, DeJesus-Hernandez, Mariely, Dormann, Dorothee, Haass, Christian, Jawaid, Ali, Kretzschmar, Hans A., Kusaka, Hirofumi, Mackenzie, Ian R. A., Munoz, David G., Neumann, Manuela, Rademakers, Rosa, Roeber, Sigrun, Yokota, Osamu   +15 more
core  

Criteria for the diagnosis of corticobasal degeneration [PDF]

, 2013
Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations.
Armstrong, Melissa J, Bak, Thomas H, Bhatia, Kailash P, Borroni, Barbara, Boxer, Adam L, Dickson, Dennis W, Grossman, Murray, Hallett, Mark, Josephs, Keith A, Kertesz, Andrew, Lang, Anthony E, Lee, Suzee E, Litvan, Irene, Miller, Bruce L, Reich, Stephen G, Riley, David E, Tolosa, Eduardo, Tröster, Alexander I, Vidailhet, Marie, Weiner, William J   +19 more
core   +1 more source

Neurotransmitter deficits from frontotemporal lobar degeneration

Brain : a journal of neurology, 2018
Murley and Rowe review the neurochemical changes arising from frontotemporal lobar degeneration, including the syndromes frontotemporal dementia, progressive supranuclear palsy and corticobasal degeneration. The evidence base from in vivo and post-mortem
A. Murley, J. Rowe
semanticscholar   +1 more source

ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration

Alzheimer's & Dementia, 2020
The ATN framework provides an in vivo diagnosis of Alzheimer's disease (AD) using cerebrospinal fluid (CSF) biomarkers of pathologic amyloid plaques (A), tangles (T), and neurodegeneration (N). ATN is rarely evaluated in pathologically confirmed patients
K. Cousins, J. Phillips, D. Irwin, Eddie B. Lee, D. Wolk, L. Shaw, H. Zetterberg, K. Blennow, Sarah E. Burke, N. Kinney, Garrett S. Gibbons, C. Mcmillan, J. Trojanowski, M. Grossman   +13 more
semanticscholar   +1 more source

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

The FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki, Wataru Onodera, Akihiko Takashima, Kotaro Kawasaki, Kazuki Imadegawa, Hikaru Kurahashi, Mizuho Oishi, Toru Asahi, Yoshiyuki Soeda   +8 more
wiley   +1 more source

Apraxia in progressive nonfluent aphasia [PDF]

, 2010
The clinical and neuroanatomical correlates of specific apraxias in neurodegenerative disease are not well understood. Here we addressed this issue in progressive nonfluent aphasia (PNFA), a canonical subtype of frontotemporal lobar degeneration that has
Rohrer, J.D., Rossor, M.N., Warren, J.D.
core  

CSF SerpinA1 in Creutzfeldt–Jakob disease and frontotemporal lobar degeneration

Annals of Clinical and Translational Neurology, 2020
SerpinA1 (alpha‐1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer’s disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal fluid (CSF)
Samir Abu-Rumeileh, S. Halbgebauer, P. Steinacker, S. Anderl-Straub, Barbara Polischi, A. Ludolph, S. Capellari, Piero Parchi, M. Otto   +8 more
semanticscholar   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Apathy and impulsivity in frontotemporal lobar degeneration syndromes [PDF]

, 2017
Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology remains elusive.
Coyle-Gilchrist, ITS, Dick, KM, Jones, PS, Lansdall, CJ, Robbins, TW, Rodriguez, PV, Rowe, JB, Wehmann, E, Wilcox, A   +8 more
core   +3 more sources

The Association Between Caregiver Psychosocial Factors and Depressive Symptoms in People With Dementia: A Systematic Review and Meta‐Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To identify and evaluate the magnitude of the association between caregiver psychosocial factors and depressive symptoms among people with dementia. Design Systematic review and meta‐analysis. Methods A systematic review with meta‐analysis used a random‐effects model to estimate the effect size.
Wenjing Ning, Shanshan Wang, Yudi Xu, Daphne Cheung   +3 more
wiley   +1 more source