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Frontotemporal Lobar Degeneration
CNS Drugs, 2012Frontotemporal Lobar Degeneration (FTLD) is an heterogeneous neurodegenerative disorder characterized by behaviour and language disturbances, associated with degeneration of the frontal and temporal lobes. Three different clinical presentations have been described, namely behavioural variant Frontotemporal Dementia (bvFTD), Semantic Dementia (SD) and ...
Enrico, Premi +2 more
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Frontotemporal lobar degeneration
2015Main imaging findings: Patterns of atrophy (CT/MRI) or functional alterations (PET/SPECT) supporting clinical diagnosis of FTLD variants: bvFTD: bilateral, often asymmetrical involvement of frontal and anterior temporal structures; nfvPPA: left posterior fronto-insular damage; svPPA: anterior temporal lobe involvement, usually left ...
Filippi M, Agosta F
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Imaging Frontotemporal Lobar Degeneration
Current Neurology and Neuroscience Reports, 2014The term frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders that target the frontal and temporal lobes. It accounts for approximately 10 % of pathologically confirmed dementias but has been demonstrated to be as prevalent as Alzheimer's disease in patients below the age of 65.
Janine, Diehl-Schmid +4 more
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From frontotemporal lobar degeneration pathology to frontotemporal lobar degeneration biomarkers
International Review of Psychiatry, 2013Frontotemporal dementia (FTD) is an increasingly recognized cause of dementia. This review discusses the different FTD clinical syndromes and frontotemporal lobar degeneration (FTLD) pathological correlates as well as new genetic and proteomic findings that have added to our understanding of FTLD pathogenesis.
Chadwick M, Hales, William T, Hu
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Frontotemporal Lobar Degeneration
Okayama Igakkai Zasshi (Journal of Okayama Medical Association)Abstract Frontotemporal lobar degeneration (FTLD) refers to the diverse neuropathologies that are the primary causes of frontotemporal dementias (FTD). FTD refers to a spectrum of progressive dementia syndromes that can be broadly grouped into behavioral (behavioral variant FTD), language (primary progressive aphasias), and motor (FTD ...
Angelina J. Polsinelli +3 more
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Frontotemporal Lobar Degeneration
Gerontology, 2001Frontotemporal lobar degeneration is the second most common form of cortical dementia in the presenium after Alzheimer’s disease. Clinically, based on consensus guidelines, three distinct disease entities can be distinguished: frontotemporal dementia, semantic dementia and progressive nonfluent aphasia. Dementia of frontal type and motor neuron disease
M. Tolnay, A. Probst
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Frontotemporal Lobar Degeneration
2017Frontotemporal dementia (FTD) is an uncommon but important form of degenerative disease characterized by clinical syndromes that result from degeneration of the frontal and temporal lobes. FTD is divided based on clinical presentation into behavioral variant FTD (bvFTD), semantic dementia, and progressive nonfluent/agrammatic aphasia.
Jonathan Graff-Radford, Keith A. Josephs
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Fluid Biomarkers of Frontotemporal Lobar Degeneration
2021A timely diagnosis of frontotemporal degeneration (FTD) is frequently challenging due to the heterogeneous symptomatology and poor phenotype-pathological correlation. Fluid biomarkers that reflect FTD pathophysiology could be instrumental in both clinical practice and pharmaceutical trials.
van der Ende, Emma, van Swieten, J.C.
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Epidemiology of Frontotemporal Lobar Degeneration
Dementia and Geriatric Cognitive Disorders, 2004A few epidemiologic studies have dealt with the prevalence of frontotemporal lobar degeneration (FTLD), including Pick’s disease. The aim of this study was to review the epidemiologic studies of FTLD in western countries and to compare them with those in Japan.
Manabu, Ikeda +2 more
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