Results 91 to 100 of about 207,768 (344)
Flax Planting Date Trial [PDF]
, 2015 Early seeding of flax generally produces the best yields and quality. Moderate temperatures and sufficient soil moisture during flowering and seed development are important for high yield and quality, and these conditions are more likely to occur with ...
Calderwood, Lily +5 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
HeliyonExtreme environmental conditions, such as high temperature, frost, low humidity and desiccating winds, are the main causes for the failure of plantation forests in Ethiopia.
Yeshifana Alemneh Mengesha +8 more
doaj +1 more source
Screening early autumn frost hardiness among progenies from Norway spruce seed orchards.
Silva Fennica, 1988 Nursery grown Norway spruce ( (L.) H. Karst.) seedlings from 12 different seed orchards were tested for early autumn frost hardiness using artificial freezing tests.
Johnsen, Øystein, Apeland, Inger
doaj +1 more source
Climate change at the ecosystem scale: a 50-year record in New Hampshire [PDF]
, 2012 Observing the full range of climate change impacts at the local scale is difficult. Predicted rates of change are often small relative to interannual variability, and few locations have sufficiently comprehensive long-term records of environmental ...
Bailey, Amey S. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Thermal modeling of Anchorage driveway culvert with addition of insulation to prevent frost heaving [PDF]
, 2017 A predominate problem in cold regions, and specifically in Anchorage, Alaska, is frost heaving pavement above culverts in residential driveways. The culvert increases heat loss in the subgrade materials during winter months and allows the soils below ...
Banzhaf, Clinton J.
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source