Results 111 to 120 of about 207,768 (344)

The Drained Strength of Bentonite Enhanced Sand [PDF]

, 1999
INTRODUCTION Barriers with a low hydraulic conductivity are used as part of waste containment systems to prevent groundwater contamination by liquids from the waste.
Cousens, T.W., Mollins, L.H., Stewart, D.I.   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Frost Damage Index: The Antipode of Growing Degree Days. [PDF]

Plant Phenomics, 2023
Tschurr F, Kirchgessner N, Hund A, Kronenberg L, Anderegg J, Walter A, Roth L.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Debris/Ice/TPS Assessment and Photographic Analysis for Shuttle Mission STS-37 [PDF]

A Debris/Ice/TPS assessment and photographic analysis was conducted for Space Shuttle Mission STS-37. Debris inspections of the flight elements and launch pad were performed before and after launch. Ice/frost conditions on the External Tank were assessed
Davis, J. Bradley, Higginbotham, Scott A., Katnik, Gregory N.   +2 more
core   +8 more sources

Frost heaving of Picea abies seedlings as influenced by soil preparation, planting technique, and location along gap-shelterwood gradients

Silva Fennica, 2009
The effects of soil preparation, planting technique and location along gap-shelterwood gradients (position and orientation) on frost heaving damage to seedlings were studied in Vindeln Experimental Forests, northern Sweden. The forest was harvested in
Chantal, Michelle, Rita, Hannu, Bergsten, Urban, Löfvenius, Mikaell, Grip, Harald   +4 more
doaj   +1 more source

Estimating the frost damage index in lettuce using UAV-based RGB and multispectral images. [PDF]

Front Plant Sci, 2023
Liu Y, Ban S, Wei S, Li L, Tian M, Hu D, Liu W, Yuan T.   +7 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effects of Meteorological Factors and Frost Injury on Flowering Stage of Apples and Pears Across Regions at Varying Altitudes

Horticulturae
Recent meteorological variability in winter and spring complicates predicting and managing frost damage in apples and pears. This study investigated the relationship between frost injury during the flowering stages of apples (‘Hongro’ and ‘Fuji’) and ...
Young-Min Choi, Sang-Baek Kim, Dong-Geun Choi, Seung-Heui Kim, Ju-Hee Song   +4 more
doaj   +1 more source

Frost damage of bricks composing a railway tunnel monument in Central Japan: field monitoring and laboratory simulation

, 2005
International audienceBricks of tunnels and bridges of Usui Pass railway (Japan) exposed to north are subject to frost damage. Average depth of erosion due to detachment of angular blocks is around 1-1.5 cm.
Kuchitsu, N., Matsuoka, N., Morii, M., Thomachot, C.   +3 more
core   +2 more sources