Results 51 to 60 of about 17,056 (260)

Incidents of damage to berm drainage ditches in cold region and countermeasures [PDF]

MATEC Web of Conferences, 2019
Berm drainage ditches may fail due to frost heave in cold and snowy areas like Hokkaido. Many of these failures are regarded to be caused by damage due to frost heave in the ground or freeze-thaw, but no sufficient measures are being taken, as ...
Sato Atsuko, Yamanashi Takahiro, Adachi Takayuki   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Variation in flower frost tolerance among seven apple cultivars and transcriptome response patterns in two contrastingly frost-tolerant selected cultivars

Open Life Sciences
This study evaluated frost tolerance in flowers of seven major apple cultivars grown in Korea to develop frost-resistant varieties for sustainable apple production under climate change. Flowers at full bloom were exposed to simulated frost conditions at −
Lee Je-Chang, Zebro Mewuleddeg, Jeong Haet-Nim, Heo Jae-Yun   +3 more
doaj   +1 more source

An Analytical Solution for the Frost Heaving Force considering the Freeze-Thaw Damage and Transversely Isotropic Characteristics of the Surrounding Rock in Cold-Region Tunnels

Advances in Civil Engineering, 2020
Frost damage is a frequent occurrence in cold regions and can threaten the normal use and structural stability of tunnel engineering projects. To accurately determine the frost heaving force and effectively evaluate the frost damage in cold-region ...
Jiabing Zhang, Xiaohu Zhang, Helin Fu, Yimin Wu, Zhen Huang, Deyue Chen   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the Possibilities of Preventing Damages by Frost.

The Proceedings of the Royal Society of Queensland, 1903
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Continuous frost causes a greater reduction in forest growth than isolated frost in the Northern Hemisphere

Nature Communications
Frost events can cause severe and often irreversible damage to leaves and canopies. The negative impacts of isolated frost events, defined as discontinuous days of extreme cold, on forests are well documented.
Hongjun Yang, Wenjing Tao, Juan Chen, Qin Yan, Yuchuan Yang, Haoyu Qiu, Junkai Ma, Josep Peñuelas, Lei Chen   +8 more
doaj   +1 more source