Results 71 to 80 of about 232,959 (351)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The thermal structure at the topside and above of polar mesosphere summer echoes over Spitsbergen 78° N [PDF]

, 2008
Simultaneous measurements of temperature and polar mesosphere summer echoes (PMSE) were performed at the polar cap (78° N) during summer 2001 and 2003.
F.-J. Lübken, J. Höffner, J. Lautenbach, M. Zecha   +3 more
core   +2 more sources

Incidents of damage to berm drainage ditches in cold region and countermeasures [PDF]

MATEC Web of Conferences, 2019
Berm drainage ditches may fail due to frost heave in cold and snowy areas like Hokkaido. Many of these failures are regarded to be caused by damage due to frost heave in the ground or freeze-thaw, but no sufficient measures are being taken, as ...
Sato Atsuko, Yamanashi Takahiro, Adachi Takayuki   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Testing of frost hardiness models for Pinus sylvestris in natural conditions and in elevated temperature.

Silva Fennica, 1996
Two dynamic models predicting the development of frost hardiness of Finnish Scots pine ( L.) were tested with frost hardiness data obtained from trees growing in the natural conditions of Finland and from an experiment simulating the predicted climatic ...
Leinonen, Ilkka, Hänninen, Heikki, Repo, Tapani   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Bio-Wicking System to Prevent Frost Heave in Alaskan Pavements: Phase II Implementation [PDF]

, 2019
Water within pavement layers is the major cause of pavement deterioration. High water content results in significant reduction in soil’s resilient behavior and an increase in permanent deformation.
Galinmoghadan, Javad, Lin, Chang, Zhang, Xiong   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Updated high-resolution grids of monthly climatic observations - the CRU TS3.10 Dataset [PDF]

, 2014
This paper describes the construction of an updated gridded climate dataset (referred to as CRU TS3.10) from monthly observations at meteorological stations across the world's land areas. Station anomalies (from 1961 to 1990 means) were interpolated into
Allen, Becker, Brohan, Easterling, Ekström, Giorgi, Groisman, Hofstra, Jones, Jones, Jones, Kuzmina, Legates, Mitchell, New, New, Nicholls, Peterson, Peterson, Peterson, Schneider, Trenberth, Vincent, Vincent, Vose, Willmott   +25 more
core   +1 more source

Experimental study on frost-formation characteristics on cold surface of arched copper sample.

PLoS ONE, 2018
The present work investigates the process of frosting formation on arched copper samples with different surface temperatures, calculated the thickness of the frost layer by using the scale method, and analyzed frost lodging, melting, and other phenomena ...
Tingkun Chen, Qian Cong, Jingfu Jin, Kwang-Leong Choy   +3 more
doaj   +1 more source