Results 41 to 50 of about 3,598 (237)
Energies, 2018 In order to solve the frosting and blockage problem of an air conditioning evaporator’s fin in winter, the nanoporous aluminum plates with low surface energy has been proposed in this paper, which are fabricated by an anodizing method and then ...
Song He +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Zhileng xuebao, 2021 The limitations of non-uniform frosting along the direction of air flow and large frost mass in the first row of the finned tube heat exchanger of an air-source heat pump under low ambient temperature may cause a short defrost interval, heating capacity ...
Xiao Hongxin +5 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
FROSTING IN MEMBRANE ENERGY EXCHANGERS [PDF]
, 2016 Frost formation in heat/energy exchangers is undesirable because it may reduce air flow through the exchanger, increase the power consumption of fans, decrease the effectiveness of the exchanger, and in extreme cases, cause physical damage to the ...
Rafatinasr, Mohammad 1985-
core
Micropatterned Aluminium Surfaces for Anti-icing and Anti-frosting Applications [PDF]
, 2021 Developing anti-icing and anti-frosting technology is vital for many different energy generation and consumption systems such as wind turbines, aircraft and heat exchangers, where ice and frost formation is a barrier for efficiency and can severely ...
Prime, Helen Elisabeth
core
Gaussian Frosting: Editable Complex Radiance Fields with Real-Time Rendering [PDF]
We propose Gaussian Frosting, a novel mesh-based representation for high-quality rendering and editing of complex 3D effects in real-time. Our approach builds on the recent 3D Gaussian Splatting framework, which optimizes a set of 3D Gaussians to ...
Guédon, Antoine, Lepetit, Vincent
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source