Results 61 to 70 of about 18,196 (278)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Spartan Daily, May 3, 2018 [PDF]
, 2018 Volume 150, Issue 40https://scholarworks.sjsu.edu/spartan_daily_2018/1039/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Soil nitrate N as influenced by annually undersown cover crops in spring cereals [PDF]
, 2003 Cover crops can reduce leaching and erosion, introduce variability into crop rotations and fix nitrogen (N) for use by the main crops. In Finland, undersowing is a suitable method for establishing cover crops in cereals.
Eriksson, Christian +3 more
core
Performance of AAOmega: the AAT multi-purpose fibre-fed spectrograph
, 2006 AAOmega is the new spectrograph for the 2dF fibre-positioning system on the Anglo-Australian Telescope. It is a bench-mounted, double-beamed design, using volume phase holographic (VPH) gratings and articulating cameras.
Churilov, V. +13 more
core +2 more sources
Pseudoeurycea longicauda [PDF]
, 1999 Number of Pages: 2Integrative BiologyGeological ...
Lynch, James F., Wake, David B.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Effect of Fin Coating on Dust Removal via a Frosting–Defrosting Process
Zhileng xuebao, 2020 To avoid deterioration in the performance of air conditioner heat exchangers after prolonged operation, the dust deposited on the fin surfaces should be removed in a timely manner.
Yang Yifei +7 more
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