Results 141 to 150 of about 2,502,626 (254)

Advanced age woman with diminished ovarian reserve obtained live birth following a zero pronuclei-derived four-cell frozen-thawed embryo transfer on day 4: a case report

Frontiers in Medicine
ObjectiveAdvanced maternal age and diminished ovarian reserve (DOR) are challenges in infertile patients for in vitro fertilization-embryo transfer (IVF-ET).
Xiao-lei Zhang, Yong-qian Chen, Ya-juan Zhang   +2 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Effect of maternal age, embryo number and quality on pregnancy outcome during frozen embryo transfer cycle

Frontiers in Endocrinology
BackgroundTo investigate the effects of maternal age, the number of transferred embryos, and embryo quality on pregnancy-related outcomes in frozen-thawed embryo transfer cycles.DesignA retrospective cohort study was conducted on 1031 frozen-thawed ...
Wenyi Gao, Weiwei Tang, Caixia Li, Yun Deng, Yao Chen, Yanru Zhang, Xiaohong Pan, Chunyan Yang, Yuanyuan Liu, Fang Xiong, Xin Jin   +10 more
doaj   +1 more source

IVF Transfer of Fresh or Frozen Embryos in Women without Polycystic Ovaries

, 2018
Original Article.BACKGROUND: Among women who are undergoing in vitro fertilization (IVF), the transfer of frozen embryos has been shown to result in a higher rate of live birth than the transfer of fresh embryos in those with infertility associated with ...
Duc T. Ha, Norman, R.J., Pham, T.D., Toan D. Pham, Bao G. Huynh, Dang, V.Q., Mol, B.W., Vuong, L.N., Vinh Q. Dang, Ho, T.M., Nguyen, L.K., Ben W. Mol, Tuong M. Ho, Huynh, B.G., Robert J. Norman, Lan N. Vuong, Ha, D.T., Linh K. Nguyen   +17 more
core   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Efficiency of embryo transfers in patients in frozen embryo transfer of in vitro fertilization

Obstetrics and gynecology: News, Opinions, Training, 2022
Yu.N. Bashankaeva, N.V. Zarochentseva, K.V. Krasnopolskaya, K.M. Isakova   +3 more
openaire   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Our experience in frozen-thaw embryo transfer cycles: The impact of different post-thaw vitrified embryo culture period.

, 2017
Vitrification technique has shown great promise for human embryo cryopreservation due to its consistent cryosurvival. The selection of medium and period of post-thawed culture for embryos survival depends on IVF laboratories practice in order to achieve ...
Ramli, Roszaman, Mohd Yatim, Hayati, Abdul Wahab, Azantee Yazmie, Mohd Bustaman, Siti Khadijah   +3 more
core  

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source