Results 101 to 110 of about 361,236 (411)
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Hepatology Communications, 2021 Acetaminophen (N‐acetyl‐para‐aminophenol [APAP]) overdose is the most common cause of drug‐induced liver injury in the Western world and has limited therapeutic options.
Deqiang Zhang +12 more
doaj +1 more source
Analysis of Mono-, Di- and Oligosaccharides by CE Using a Two-Stage Derivatization Method and LIF Detection. [PDF]
, 2009 A sensitive CE with LIF method has been developed for quantitative analysis of small carbohydrates. In this work, 17 carbohydrates including mono-, di- and oligosaccharides were simultaneously derivatized with 4-fluoro 7-nitrobenzo furazane (NBD-F) via ...
Barrett, DA +4 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
BMC GastroenterologyBackground Food malabsorption and intolerance is implicated in gastrointestinal symptoms among patients with irritable bowel syndrome (IBS). Key triggers include fructose and fructan.
Twan Sia +18 more
doaj +1 more source
Bayesian inference based process design and uncertainty analysis of simulated moving bed chromatographic systems [PDF]
, 2019 Prominent features of simulated moving bed (SMB) chromatography processes in the downstream processing is based on the determination of operating conditions. However, effects of different types of uncertainties have to be studied and analysed whenever the triangle theory or numerical optimization approaches are applied.
arxiv +1 more source
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease
Nutrients, 2017 Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these metabolic diseases remains debated.
K. T. ter Horst, M. Serlie
semanticscholar +1 more source
Sweet but Bitter: Focus on Fructose Impact on Brain Function in Rodent Models
Nutrients, 2020 Fructose consumption has drastically increased during the last decades due to the extensive commercial use of high-fructose corn syrup as a sweetener for beverages, snacks and baked goods. Fructose overconsumption is known to induce obesity, dyslipidemia,
M. Spagnuolo, S. Iossa, L. Cigliano
semanticscholar +1 more source
Fructose Alters Cell Survival and Gene Expression in Microglia and Neuronal Cells Lines [PDF]
, 2016 Purpose: Microglia are macrophages that are found primarily in the CNS and play a crucial role in maintaining a healthy brain by engulfing invading microorganisms, releasing inflammatory mediators, and pruning dead cells.
DeNapoli, Susan +3 more
core +1 more source
Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis [PDF]
, 2013 Previous models of glycolysis in the sleeping sickness parasite Trypanosoma brucei assumed that the core part of glycolysis in this unicellular parasite is tightly compartimentalized within an organelle, the glycosome, which had previously been shown to ...
Achcar +30 more
core +1 more source