Results 121 to 130 of about 395,783 (395)

Molecular aspects of fructose metabolism and metabolic disease.

Cell Metabolism, 2021
M. Herman, M. Birnbaum
semanticscholar   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Repercussions of low fructose-drinking water in male rats

Anais da Academia Brasileira de Ciências, 2019
Fructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis.
CAROLINA A. MIRANDA, TATIELE E. SCHÖNHOLZER, EDUARDO KLÖPPEL, YURI K. SINZATO, GUSTAVO T. VOLPATO, DÉBORA C. DAMASCENO, KLEBER E. CAMPOS   +6 more
doaj   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

Diabetes, Metabolic Syndrome and Obesity, 2019
Brandon H Mai, Liang-Jun YanDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USAAbstract: The increased consumption of fructose in the average diet through ...
Mai BH, Yan LJ
doaj  

40 years of adding more fructose to high fructose corn syrup than is safe, through the lens of malabsorption and altered gut health–gateways to chronic disease

Nutrition Journal
Labels do not disclose the excess-free-fructose/unpaired-fructose content in foods/beverages. Objective was to estimate excess-free-fructose intake using USDA loss-adjusted-food-availability (LAFA) data (1970–2019) for high fructose corn syrup (HFCS) and
Luanne Robalo DeChristopher
doaj   +1 more source

Effects of Fructose in a Chemically Defined Maturation Medium on Oocyte Maturation and Parthenogenetic Embryo Development in Pigs

Journal of Animal Reproduction and Biotechnology, 2017
The objective of this study was to determine the effect of fructose that was supplemented to a chemically defined in Vitro maturation (IVM) medium on oocyte maturation and embryonic development after parthenogenesis in pigs.
Hyeji Shin, Minji Kim, Joohyeong Lee, Seung Tae Lee, Choon-Keun Park, Sang-Hwan Hyun, Eunsong Lee   +6 more
doaj   +1 more source

Observations on the water distribution and extractable sugar content in carrot slices after pulsed electric field treatment [PDF]

, 2014
peer-reviewedThe impact of pulsed electric field (PEF) processing conditions on the distribution of water in carrot tissue and extractability of soluble sugars from carrot slices was studied.
Aguilo-Aguayo, Ingrid, Brunton, Nigel, Downey, Gerard, Keenan, Derek F., Lyng, James G., Rai, Dilip K.   +5 more
core   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Fructose-induced metabolic reprogramming of cancer cells

Frontiers in Immunology
Excess dietary fructose consumption has been long proposed as a culprit for the world-wide increase of incidence in metabolic disorders and cancer within the past decades.
Kenneth K. Y. Ting, Kenneth K. Y. Ting
doaj   +1 more source