Results 291 to 300 of about 288,416 (369)

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

open access: yesiMeta, EarlyView.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao   +9 more
wiley   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

open access: yesiMeta, EarlyView.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen   +21 more
wiley   +1 more source

Temporal response patterns of human gut microbiota to dietary fiber

open access: yesiMeta, EarlyView.
In this study, 19 overweight participants, with or without type 2 diabetes mellitus, underwent 14 days of normal‐diet observation followed by 14 days of dietary fiber intervention. Fecal samples and continuous glucose monitoring data were collected daily throughout the 28‐day period.
Xiaotong Lin   +5 more
wiley   +1 more source

Fructose induces inflammatory activation in macrophages and microglia through the nutrient-sensing ghrelin receptor. [PDF]

open access: yesFASEB J
Shen Z   +9 more
europepmc   +1 more source

Interfacial adhesion effects of liquid metal printed electronics on general substrates: Mechanisms and applications

open access: yesInfoMat, EarlyView.
Printed electronics technology is known for its low cost, large area, ease of operation, and high speed, making it suitable for flexible electronic devices. Liquid metals, particularly gallium‐based alloys, are ideal for creating stretchable electronics due to their conductivity.
Chunxue Wan   +5 more
wiley   +1 more source

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