Results 141 to 150 of about 3,978,531 (376)

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao   +15 more
wiley   +1 more source

Computational molecular engineering as an emerging technology in process engineering [PDF]

open access: yesarXiv, 2013
The present level of development of molecular force field methods is assessed from the point of view of simulation-based engineering, outlining the immediate perspective for further development and highlighting the newly emerging discipline of Computational Molecular Engineering (CME) which makes basic research in soft matter physics fruitful for ...
arxiv  

Contextual Lensing of Universal Sentence Representations [PDF]

open access: yesarXiv, 2020
What makes a universal sentence encoder universal? The notion of a generic encoder of text appears to be at odds with the inherent contextualization and non-permanence of language use in a dynamic world. However, mapping sentences into generic fixed-length vectors for downstream similarity and retrieval tasks has been fruitful, particularly for ...
arxiv  

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu   +8 more
wiley   +1 more source

Improving Distributed Representations of Tweets - Present and Future [PDF]

open access: yesarXiv, 2017
Unsupervised representation learning for tweets is an important research field which helps in solving several business applications such as sentiment analysis, hashtag prediction, paraphrase detection and microblog ranking. A good tweet representation learning model must handle the idiosyncratic nature of tweets which poses several challenges such as ...
arxiv  

Estimation of Genetic Parameter for Quantitative Characters of Pepper (Capsicum annuum L.) [PDF]

open access: yes, 2014
The research was conducted at Leuwikopo Experimental Field and Plant Breeding Laboratory of IPB, Dramaga, Bogor, West Java, Indonesia from October 2012 to April 2013.
Rosidah, Syaidatul, Syukur, Muhamad
core   +2 more sources

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

open access: yesAdvanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang   +11 more
wiley   +1 more source

Evaluation of the effect of growing area and different directions of tree on physiological browning and some morphological traits of fruits in plum (Prunus saliciana cv. Shablon( [PDF]

open access: yesفیزیولوژی محیطی گیاهی, 2019
Plum flesh browning is one of the most important disorders in Golestan. This research is aimed to evaluate the effects of climatic conditions on this disorder and other physiochemical traits of the fruit.
Seyyed Mojtaba Hosseini   +2 more
doaj  

Minimal elastic networks [PDF]

open access: yesarXiv, 2017
We consider planar networks of three curves that meet at two junctions with prescribed equal angles, minimizing a combination of the elastic energy and the length functional. We prove existence and regularity of minimizers, and we show some properties of the minimal configurations.
arxiv  

Design Principles From Natural Olfaction for Electronic Noses

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
Unlocking “universal smell” requires integrating key principles of natural olfactory systems: modulation of gas transport, utilization of non‐selective sensing elements, chemical filters akin to the biological mucus layer to separate compounds, refined context‐specific signal integration, and more.
Haritosh Patel   +9 more
wiley   +1 more source

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