Results 51 to 60 of about 9,636 (257)

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco   +8 more
wiley   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

open access: yesBMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song   +10 more
wiley   +1 more source

Evidence for positive selection in the gene fruitless in Anastrepha fruit flies

open access: yesBMC Evolutionary Biology, 2010
Background Many genes involved in the sex determining cascade have indicated signals of positive selection and rapid evolution across different species.
de Brito Reinaldo A, Sobrinho Iderval S
doaj   +1 more source

Symbolic or Substantive Action: Intent, Effort, and Results

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Many firms have made ambitious climate pledges since the Paris Agreement of 2015. These pledges may be symbolic or substantive, but the literature is fragmented in defining these two terms. We propose a conceptual framework with three frames to delineate symbolic from substantive action: Intent—underlying motivations for engaging in climate ...
Vincent Xinyi Gu   +1 more
wiley   +1 more source

Market and Nonmarket Strategies in Focus: How Entrepreneurs Tackling the Grand Challenge of Waste Management Navigate Institutional and Market Adversity in Ghana

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Waste management remains a critical grand challenge in African countries. While entrepreneurship has been a viable strategy for addressing this challenge, it is fraught with constraints. This study investigates the strategies orchestrated by entrepreneurs to navigate adversity in Waste management and ensure the social and economic viability of
Tahiru Azaaviele Liedong   +3 more
wiley   +1 more source

Was kann familiensoziologische Theorie? Korreferat zum Beitrag von Günter Burkart

open access: yesJournal of Family Research, 2006
This article discusses current theoretical debates within family sociology. It is argued that many of these debates are fruitless. Instead, the author argues that models inspired by family economics have proven to be very helpful for family research ...
Josef Brüderl
doaj   +1 more source

The Tree of Life Synagogue Attack: A Terrorist Radicalization Assessment Protocol‐18 Examination of Pre‐Attack Warnings and Post‐Attack Contagion and Copycat Effects

open access: yesBehavioral Sciences &the Law, EarlyView.
ABSTRACT This is a retrospective case study of an antisemitic lone actor terrorist who completed the deadliest attack against the Jewish community in American history. The analysis through the lens of the Terrorist Radicalization Assessment Protocol (TRAP‐18) finds that 72% of the warning indicators were present, including four proximal warning ...
Molly Amman, Julia Kupper, J. Reid Meloy
wiley   +1 more source

“Evil is Real and Attitude is Everything”: Applying Shattered Assumptions Theory to Worldview Changes Following Wrongful Conviction

open access: yesBehavioral Sciences &the Law, EarlyView.
ABSTRACT Wrongful convictions continue to occur at high rates. Research has revealed that negative posttraumatic cognitive changes are a risk factor for the development and maintenance of posttraumatic stress disorder, yet little research has examined whether exonerees experience posttraumatic cognitive changes, such as changes to their worldview. Thus,
Kathryn A. Thomas   +3 more
wiley   +1 more source

How to Disagree About Argument Schemes

open access: yesInformal Logic, 2016
Argumentation theorists often disagree about which scheme best represents a given type of argument (e.g. argument by analogy, argument from authority, inference to the best explanation).
Fábio Perin Shecaira
doaj   +3 more sources

Living Microbial Drugs

open access: yesChemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik   +3 more
wiley   +1 more source

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