Results 11 to 20 of about 213 (60)

Revisiting zoonotic human African trypanosomiasis control in Uganda

, 2015
Objectives: Human migration and concomitant HIV infections are likely to bring about major changes in the epidemiology of zoonotic parasitic infections. Human African trypanosomiasis (HAT) control is particularly fraught with intricacies.
Menon, Sonia, Nshimyumukiza, Leon, Rossi, Rodolfo, Zinszer, Kate   +3 more
core   +1 more source

Hidden Markov Models for Gene Sequence Classification: Classifying the VSG genes in the Trypanosoma brucei Genome

, 2015
The article presents an application of Hidden Markov Models (HMMs) for pattern recognition on genome sequences. We apply HMM for identifying genes encoding the Variant Surface Glycoprotein (VSG) in the genomes of Trypanosoma brucei (T.
Alvarez-Valin, Fernando, Basterrech, Sebastián, Guerberoff, Gustavo, Mesa, Andrea   +3 more
core   +1 more source

Forecasting Human African Trypanosomiasis Prevalences from Population Screening Data Using Continuous Time Models [PDF]

, 2016
To eliminate and eradicate gambiense human African trypanosomiasis (HAT), maximizing the effectiveness of active case finding is of key importance. The progression of the epidemic is largely influenced by the planning of these operations.
Hasker, E.C. (Epco C.), Klundert, J.J. (Joris) van de, Lumbala, C. (Crispin), Lutumba, P. (Pascal), Vlas, S.J. (Sake) de, Vries, H. (Harwin) de, Wagelmans, A.P.M. (Albert)   +6 more
core   +5 more sources

Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense. [PDF]

, 2016
A new series of N-substituted S-(2,4-dinitrophenyl)glutathione dibutyl diesters were synthesized to improve in vitro anti-protozoal activity against the pathogenic parasites Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania donovani.
Croft, Simon L, D'Silva, Claudius, Daunes, Sylvie, Yardley, Vanessa   +3 more
core   +2 more sources

Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules:Synthesis, electrochemical and SAR study [PDF]

, 2018
International audienceTo study the antiparasitic 8-nitroquinolin-2(1H)-one pharmacophore, a series of 31 derivatives was synthesized in 1-5 steps and evaluated in vitro against both Leishmania infantum and Trypanosoma brucei brucei.
Azas, Nadine, Boudot, Clotilde, Bourgeade-Delmas, Sandra, Boutet-Robinet, Elisa, Courtioux, Bertrand, Fairlamb, Alan, Hutter, Sébastien, Laget, Michèle, Moreau, Alain, Mothes, Emmanuelle, Paloque, Lucie, Pedron, Julien, Pratviel, Geneviève, Sournia-Saquet, Alix, Stigliani, Jean-Luc, Valentin, Alexis, Vendier, Laure, Verhaeghe, Pierre, Wyllie, Susan   +18 more
core   +4 more sources

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]

, 2017
Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam, Horn, David, Konno, Aya, Kumar, Ambika, Meredith, Emma Louise, Seifert, Karin, Szular, Joanna, Wilkinson, Shane R.   +7 more
core   +4 more sources

Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei [PDF]

, 2017
Leucine aminopeptidase (LAP) is found in all kingdoms of life and catalyzes the metal-dependent hydrolysis of the N-terminal amino acid residue of peptide or amino acyl substrates.
Alvarez, Arastu-Kapur, Aslanidis, Battye, Bhosale, Bolte, Botbol, Burley, Cadavid-Restrepo, Cappiello, Carpenter, Castillo-Acosta, Castillo-Acosta, Charlier, Chatelain, Chen, Clayton, Cowtan, Cullen, Emsley, Estévez, Evans, Gourlay, Gu, Harbut, Jia, Kale, Kim, Kim, Klemba, Knowles, Kraft, Krissinel, Krissinel, Li, McCoy, McGowan, McNicholas, Mordier, Morty, Murshudov, Nakai, Paul, Peña-Diaz, Pérez, Rozen, Schindelin, Scranton, Sharma, Solé, Stack, Stirling, Sträter, Sträter, Sundar, Trochine, Umezawa, Vagin, Winn, Winter, Wirtz, World Health Organization, World Health Organization, Zheng   +63 more
core   +2 more sources

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase [PDF]

, 2017
African trypanosomiasis is a parasitic disease affecting 5000 humans and millions of livestock animals in sub-Saharan Africa every year. Current treatments are limited, difficult to administer and often toxic causing long term injury or death in many ...
Alsford, Baker, Blum, Blum, Brun, Chen, Fevre, Gareth Williams, Jacobs, Jamie Laverick, John Atack, Kau-Ming, Kennedy, Kido, Kido, Lewis E. Pennicott, Michael Paradowski, Minagawa, Mori, Morrison, Muhanguzi, Nihei, Nihei, Oran G. O'Doherty, Paul Beswick, Rollo, Ryan A. West, Saimoto, Saimoto, Saimoto, Salgado, Shiba, Simon E. Ward, Srinivasa P.S. Rao, Stich, Talamás, The, Thomson, Trevor Askwith, Vanlerberghe, WHO, WHO Trypanosomiasis, Wilson, Xie, Yabu, Yabu   +45 more
core   +2 more sources

ANTI-TRYPANOSOMA ACTIVITY OF ETHANOLIC EXTRACT OF NEEM LEAF (Azadirachta indica) ON Trypanosoma evansi IN RATS (Rattus norvegicus) [PDF]

, 2017
The aim of this study was to determine the effect of neem leaf extract (Azadirachta indica) on parasitemia of rats infected with Trypanosoma evansi (T. evansi) Aceh local isolate.
Asmilia, Nuzul, Azhar, Al, Erina, Erina, Fahrimal, Yudha, Maghfirah, Siti, Rinidar, Rinidar   +5 more
core   +2 more sources

Evolution of bovine Trypanosomosis by Trypanosoma vivax in Formosa (Argentina). Years 2007-2012 and its potential spread in the country [PDF]

, 2013
En base al diagnóstico parasitológico para para tripanosomas de bovinos, se describe la evolución de la onda epizoótica del T. vivax iniciada en Argentina hacia finales del año 2006.
Giménez, Juana Noemí, Mancebo, Orlando Antonio, Monzon, Carlos Manuel, Russo, Ana Maria   +3 more
core   +1 more source