Results 281 to 290 of about 214,536 (370)

Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys

open access: yesClinical Endocrinology, Volume 103, Issue 2, Page 185-192, August 2025.
ABSTRACT Objective To describe the bioactivity of circulating androgens during pubertal transition as determined by an in vitro bioassay assessing androgen receptor (AR) activation, and to compare these findings with circulating concentrations of total testosterone (total T) measured by LC‐MS/MS.
Andrés Felipe Ø. Fritzbøger   +10 more
wiley   +1 more source

Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth

open access: yesThe FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Obesity reduces in vitro fertilization pregnancy success, with significant decreases in the number of retrieved oocytes, mature oocytes, and cleavage embryos. Mevalonic acid rescues potential productive toxicity of the lipid‐lowering drug simvastatin in follicular development.
Fei Mao   +8 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray   +2 more
wiley   +1 more source

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