Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice [PDF]
Journal of Ovarian Research, 2019 Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still ...
Yuya Fujibe +11 more
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Follicle-stimulating hormone (FSH) activates extracellular signal-regulated kinase phosphorylation independently of beta-arrestin- and dynamin-mediated FSH receptor internalization [PDF]
Reproductive Biology and Endocrinology, 2006 Background The follicle-stimulating hormone receptor (FSH-R) is a seven transmembrane spanning receptor (7TMR) which plays a crucial role in male and female reproduction.
Crepieux Pascale +4 more
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The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study [PDF]
BMC Pregnancy and Childbirth, 2018 Background Single nucleotide polymorphism of the follicle-stimulating hormone (FSH) receptor (FSHR) is an important marker of ovarian function. However, its role in female fecundity remains debatable.
Birute Zilaitiene +5 more
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β-Arrestin 1 Differentially Modulates cAMP and ERK Pathways Downstream of the FSH Receptor [PDF]
Current Issues in Molecular BiologyThis study compared the gonadotropin gene sequences (LH and FSH subunits) of Cynomolgus and Rhesus monkeys and produced recombinant single-chain LHβ/α and FSHβ/α proteins. The α- and FSHβ-subunit sequences were identical between species, while LHβ showed
Sei Hyun Park +8 more
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Pharmacogenetics of FSH Action in the Male [PDF]
Frontiers in Endocrinology, 2019 Male infertility is a major contributor to couple infertility, however in most cases it remains “idiopathic” and putative treatment regimens are lacking.
Maria Schubert +2 more
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Novel FSH receptor heterodimer may be related to the high prolificacy of Jintang black goat
Animal Research and One HealthFollicle‐stimulating hormone (FSH) is the central hormone of the mammalian reproductive system. It targets the FSH receptor (FSHR), a member of the G protein‐coupled receptor family, to induce the FSH signal transduction.
Ye Cao +8 more
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Changes of FSH and LH receptors expressions in rat testis after methamphetamine exposure [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2021 Methamphetamine (METH), the most widely used psychostimulant in Thailand, has been reported to have harmful effects on testicular functions and sperm quality, but its mechanisms are still unclear.
Paweena Kaewman +2 more
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A Novel Follitropin Analog Inhibits Follitropin Activity In Vitro
Pharmaceutics, 2021 Follitropin (FSH) is a heterodimeric protein composed of an α subunit that is shared with the glycoprotein hormone family, including lutropin (LH), thyrotropin (TSH), human choriogonadotropin (hCG), and a unique β specific subunit.
Naiel Azzam +2 more
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Frontiers in Endocrinology, 2022 Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans.
Viktor Y. Butnev +7 more
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Frontiers in Endocrinology, 2022 Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and complex pathways.
Niamh S. Sayers +6 more
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