Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]
, 2020 Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger +10 more
core +1 more source
Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs [PDF]
, 2015 Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs.
Belmonte, Norberto Miguel +8 more
core +2 more sources
An overview of FSH-FSHR biology and explaining the existing conundrums
Journal of Ovarian Research, 2021 FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed intriguing that despite being researched upon for about 90 years, there is still so much more to learn about FSH-FSHR biology.
Deepa Bhartiya, Hiren Patel
doaj +1 more source
Pilot Study: FSHR Expression in Neuroendocrine Tumors of the Appendix
Journal of Clinical Medicine, 2023 Appendix neuroendocrine neoplasm (ANEN) treatment is based on tumor size and proliferation markers. Recently, the role of the follicle-stimulating hormone receptor (FSHR) from the clinical perspective has also been increasingly discussed. The FSHR is expressed in the endothelial cells of both intratumoral and peritumoral blood vessels, where it ...
Dariusz Starzyński +12 more
openaire +2 more sources
Nature Communications, 2023 Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al.
Jia Duan +14 more
doaj +1 more source
Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells [PDF]
, 2016 Expression of follicle-stimulation hormone receptor (FSHR) is confined to gonads and at low levels to some extragonadal tissues like human umbilical vein endothelial cells (HUVEC). FSH-FSHR signaling was shown to promote HUVEC angiogenesis and thereafter
Akerfelt, Malin +11 more
core +1 more source
Characterization of polymorphisms in the follicle-stimulating hormone receptor and insulin-like growth factor-1 genes and their association with fertility traits in Jawa-Brebes cows [PDF]
Veterinary World, 2023 Background and Aim: The availability of fertility markers is crucial for maintaining, protecting, and improving the genetics of Jawa-Brebes (Jabres) cows. Follicle-stimulating hormone receptor (FSHR) and insulin-like growth factor-1 (IGF-1) play critical
Slamet Hartanto +4 more
doaj +1 more source
In Vitro Effects of the Endocrine Disruptor p,p’-DDT on Human Follitropin Receptor [PDF]
, 2016 BACKGROUND: 1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene (p,p\u27-DDT) is a persistent environmental endocrine disruptor (ED). Several studies have shown an association between p,p\u27-DDT exposure and reproductive abnormalities ...
B. Schiøtt +9 more
core +5 more sources
The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR −29G > A Affects Androgen Production in Normal Human Small Antral Follicles [PDF]
Frontiers in Endocrinology, 2017 Follicle-stimulating hormone receptors (FSHRs) are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism (SNP) FSHR -29G > A (rs1394205) on hormonal conditions in ...
Tanni Borgbo +7 more
openaire +6 more sources
Frontiers in Pharmacology, 2020 Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal activity of GPCRs is membrane trafficking.
Silvia Sposini +10 more
doaj +1 more source