Results 71 to 80 of about 3,023 (153)

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, Volume 13, Issue 55, 5 October 2026.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists

Frontiers in Endocrinology, 2019
The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, with ...
Ross C. Anderson, Claire L. Newton, Robert P. Millar, Robert P. Millar   +3 more
doaj   +1 more source

Effects of FSHR Gene Variants on Ovarian Response

INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2020
The researchers would like to thank Ondokuz Mayis University BAP for supporting the project (PYO.TIP.1904.15.029).
Gulhan, Cayci, Ozdemir, Ayse Z., Onal, Mesut, Tural, Sengul, Guven, Davut, Kocak, Idris   +5 more
openaire   +2 more sources

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, Volume 101, Issue 5, Page 2265-2278, October 2026.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Structural alignment between FSHR-AF2 (cyan structure) and the FSHR-TM (orange structure); for reference, Cα of cysteine residues are depicted as spheres in yellow and in blue for the FSHR-TM and FSHR-AF2, respectively. The open intracellular conformation suggests that the models corresponds to the activated conformation.

Structural alignment between FSHR-AF2 (cyan structure) and the FSHR-TM (orange structure); for reference, Cα of cysteine residues are depicted as spheres in yellow and in blue for the FSHR-TM and FSHR-AF2, respectively.
Alfredo Ulloa-Aguirre (2422720), Eduardo Jardón-Valadez (6000542)   +1 more
core   +1 more source

Разработка методов генотипирования однонуклеотидных полиморфизмов генов fshr и lhcgr крупного рогатого скота на основе ПЦР в режиме реального времени [PDF]

, 2021
крс, пцр, гены, ген fshr, ген lhcgr, полиморфизм, однонуклеотидный полиморфизм, генотипированиеГены рецепторов фолликулостимулирующего (fshr) и лютеинизирующего (lhcgr) гормонов являются наиболее перспективными генетическими маркерами репродуктивного ...
Ковальчук, С. Н.
core  

The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR −29G > A Affects Androgen Production in Normal Human Small Antral Follicles [PDF]

Frontiers in Endocrinology, 2017
Follicle-stimulating hormone receptors (FSHRs) are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism (SNP) FSHR -29G > A (rs1394205) on hormonal conditions in ...
Tanni Borgbo, Tanni Borgbo, Hana Klučková, Milan Macek, Jana Chrudimska, Stine Gry Kristensen, Lise Lotte Hansen, Claus Yding Andersen   +7 more
openaire   +5 more sources

Systems Pharmacology and Multitarget Modulation of Letrozole–HFD‐Induced Polycystic Ovarian Syndrome by Fruit Pulp of Prunus armeniaca

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Integrated systems pharmacology and in vivo evaluation reveal that hydroalcoholic extract of fruit pulp of Prunus armeniaca (HAE of FPPA) ameliorates letrozole–HFD‐induced PCOS through multitarget modulation. Network analysis identifies 105 shared targets enriched in PI3K/Akt, MAPK, HIF‐1, and inflammatory pathways, while treatment improves hormonal ...
Ratna Priya, Nitish Singh Jangwan, Swati Dobhal, Shradha Bisht, Mamta F. Singh   +4 more
wiley   +1 more source

Transgenic mouse models to study follicle-stimulating hormone receptor (FSHR) function in reproduction

International audienceFollicle-stimulating hormone (FSH) binds to G protein-coupled FSH receptors (FSHR) expressed on ovarian granulosa cells in low abundance.
Gourdon, Juliette, Rajendra Kumar, T, Reiter, Eric   +2 more
core   +1 more source

Differential Gene Expression of Mesenchymal Stromal Cell and Granulosa Cell Markers in Equine Follicular Aspirates

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Equine follicular aspirates obtained during ovum pick‐up contain a heterogeneous mixture of mesenchymal stromal cells (MSC) and granulosa cells (GC). This study evaluates how selective isolation and expansion of MSC decrease GC populations.
María del Prado Soriano‐Campos, Carmen Cristina Muñoz‐García, Marcos Luis‐Calero, Marian del Olmo‐Ortiz, Alejandro Gallardo‐Soler, Beatriz Macías‐García, Lauro González‐Fernández   +6 more
wiley   +1 more source