Results 81 to 90 of about 9,973 (237)
Effects of FSHR Gene Variants on Ovarian Response
The researchers would like to thank Ondokuz Mayis University BAP for supporting the project (PYO.TIP.1904.15.029).
Gulhan, Cayci +5 more
openaire +2 more sources
Distal regulatory elements are required for Fshr expression, in vivo [PDF]
The gonadotropin follicle-stimulating hormone (FSH) is required for initiation and maintenance of normal gametogenesis and acts through a specific, cell-surface receptor (Fshr) present only on Sertoli and granulosa cells in the gonads. Despite extensive examination of the transcriptional mechanisms regulating Fshr, the sequences directing its ...
Brian P, Hermann +3 more
openaire +2 more sources
Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists
The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, with ...
Ross C. Anderson +3 more
doaj +1 more source
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai +12 more
wiley +1 more source
Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM).
J. Laven
semanticscholar +1 more source
Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara +12 more
wiley +1 more source
ABSTRACT Background The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin‐like growth factor (IGF) bioavailability through cleavage of insulin‐like growth factor‐binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep reproductive traits remains underexplored. Objective This
Yuanyuan Wang +5 more
wiley +1 more source
Follicle-stimulating hormone receptor (FSHR), which is expressed only on Sertoli cells and plays a key role in spermatogenesis, has been paid attention for its potential in male contraception vaccine research and development.
Cheng Xu +9 more
doaj +1 more source
Spatial Transcriptomic Characteristics of the Aging Human Ovary
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang +14 more
wiley +1 more source
Humanized mice offer new insight into immune‐hormonal changes during menopause. Traditional models lack accuracy in replicating human menopause physiology. Functional foods may ease symptoms but need testing in human‐relevant systems. Combining humanized mice with diet research can improve women's health outcomes.
Nisansala Chandimali +6 more
wiley +1 more source

