Results 81 to 90 of about 9,973 (237)

Effects of FSHR Gene Variants on Ovarian Response

INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2020
The researchers would like to thank Ondokuz Mayis University BAP for supporting the project (PYO.TIP.1904.15.029).
Gulhan, Cayci, Ozdemir, Ayse Z., Onal, Mesut, Tural, Sengul, Guven, Davut, Kocak, Idris   +5 more
openaire   +2 more sources

Distal regulatory elements are required for Fshr expression, in vivo [PDF]

Molecular and Cellular Endocrinology, 2007
The gonadotropin follicle-stimulating hormone (FSH) is required for initiation and maintenance of normal gametogenesis and acts through a specific, cell-surface receptor (Fshr) present only on Sertoli and granulosa cells in the gonads. Despite extensive examination of the transcriptional mechanisms regulating Fshr, the sequences directing its ...
Brian P, Hermann, Kaori I, Hornbaker, Rengasamy R M, Maran, Leslie L, Heckert   +3 more
openaire   +2 more sources

Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists

Frontiers in Endocrinology, 2019
The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, with ...
Ross C. Anderson, Claire L. Newton, Robert P. Millar, Robert P. Millar   +3 more
doaj   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

Cell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai, Minami Takahashi, Jin Kobayashi, Takahiro Eitsuka, Himari Matsusaka, Taku Ozaki, Eriko Sugano, Hiroshi Tomita, Yuan Xu, Kazuhiro Kawamura, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +12 more
wiley   +1 more source

Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS)

Frontiers in Endocrinology, 2019
Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM).
J. Laven
semanticscholar   +1 more source

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
ABSTRACT Background The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin‐like growth factor (IGF) bioavailability through cleavage of insulin‐like growth factor‐binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep reproductive traits remains underexplored. Objective This
Yuanyuan Wang, Wenqiang Xu, Benmeng Liang, Shujing Li, Wenping Hu, Mingxing Chu   +5 more
wiley   +1 more source

The preparation and application of N-terminal 57 amino acid protein of the follicle-stimulating hormone receptor as a candidate male contraceptive vaccine

Asian Journal of Andrology, 2014
Follicle-stimulating hormone receptor (FSHR), which is expressed only on Sertoli cells and plays a key role in spermatogenesis, has been paid attention for its potential in male contraception vaccine research and development.
Cheng Xu, Ying-Chun Li, Hua Yang, Yan Long, Min-Jian Chen, Yu-Feng Qin, Yan-Kai Xia, Ling Song, Ai-Hua Gu, Xin-Ru Wang   +9 more
doaj   +1 more source

Spatial Transcriptomic Characteristics of the Aging Human Ovary

Aging Cell, Volume 25, Issue 1, January 2026.
Troughing constructing a comprehensive spatiotemporal aging atlas on young and aged human ovaries, we revealed distinct cell types, cellular interactions, and aging‐associated gene expression changes due to aging. Specially, we detected an increase in DLK1:NOTCH3 expression which may contribute to the dysregulation of ovarian functions.
Meiling Zhang, Fanghao Guo, Qing Zhang, Qianhui Hu, Di Sun, Yongjian Ma, Yanquan Li, Mengxi Guo, Haixia Ding, Ying Guo, Baicai Yang, Songmao Li, Ningxia Sun, Yuxuan Zheng, Wen Li   +14 more
wiley   +1 more source

Humanized Mouse Models as a Cellular Platform for Investigating Immune‐Hormonal Crosstalk and Therapeutic Strategies in Menopause

Aging Cell, Volume 25, Issue 1, January 2026.
Humanized mice offer new insight into immune‐hormonal changes during menopause. Traditional models lack accuracy in replicating human menopause physiology. Functional foods may ease symptoms but need testing in human‐relevant systems. Combining humanized mice with diet research can improve women's health outcomes.
Nisansala Chandimali, Jaehoon Bae, Sun Hee Cheong, Seon Gyeong Bak, Yeon‐Yong Kim, Ji‐Su Kim, Seung‐Jae Lee   +6 more
wiley   +1 more source