Results 111 to 120 of about 114,221 (304)

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

open access: yesPLoS ONE, 2010
Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased food intake.
Tung, Yi-Chun Loraine   +6 more
openaire   +6 more sources

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

open access: yesAdvanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen   +9 more
wiley   +1 more source

FTO Gene Polymorphisms Contribute to the Predisposition and Radiotherapy Efficiency of Nasopharyngeal Carcinoma

open access: yesPharmacogenomics and Personalized Medicine, 2021
Feng Xiao, Jianrong Zhou School of Nursing, Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Jianrong ZhouSchool of Nursing, Chongqing Medical University, No. 1 Changda Road, Jiulongpo District, Chongqing, 400016,
Xiao F, Zhou J
doaj  

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

open access: yesAdvanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li   +9 more
wiley   +1 more source

Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents

open access: yesAdipocyte, 2019
This study is the first to identify the effects of FTO genotype on the interactions between the level of macro-nutrients intake and the expression level of fat mass and obesity associated (FTO) and homeobox transcription factor iriquois-3 (IRX3) genes ...
Saeid Doaei   +9 more
doaj   +1 more source

Diffusion‐Driven Targeted Passivation of Selenium Vacancies via an I‐Doped CdS Buffer Layer for Efficient Sb2Se3 Solar Cells

open access: yesAdvanced Science, EarlyView.
Iodine incorporation into the CdS buffer layer induces spontaneous anion diffusion and selectively passivates selenium vacancies in Sb2Se3 absorbers. The formation of low‐energy, charge‐neutral ISe defects effectively suppresses non‐radiative recombination, resulting in a substantially enhanced open‐circuit voltage and boosting the device efficiency to
Luyan Shen   +6 more
wiley   +1 more source

GENETIC ASPECTS OF ADULT OBESITY FORMATION

open access: yesМедицина в Кузбассе, 2023
Obesity is a multifactorial disease, and the genetic component occupies an important place in its pathogenesis. One of the most studied and closely associated with monogenic obesity is the FTO (fat mass and obesity associated) gene.
Варвара Ивановна Минина   +10 more
doaj  

Engineered Interfacial Control for Suppression of Phase Instability: Operando Visualization from Device to Module Scale

open access: yesAdvanced Science, EarlyView.
Operando real‐time current density–voltage absorption spectroscopy visualizes spatial phase evolution in mixed‐halide perovskites from device to module scale. Phase instability preferentially initiates in regions with insufficient carrier extraction, revealing electrical boundary conditions as governing factors.
Hangyeol Choi   +8 more
wiley   +1 more source

Active Fraction of Polyrhachis Vicina Roger (AFPR) Ameliorate Depression Induced Inflammation Response by FTO/miR-221-3p/SOCS1 Axis

open access: yesJournal of Inflammation Research, 2023
Junhui He,1,* Jiaxiu Xie,1,* Guili Zhou,2,* Chunlian Jia,2 Dongbo Han,2 Dongmei Li,1 Jie Wei,1 Yi Li,1 Renshan Huang,1 Chunlian Li,1 Bo Wang,3 Chao Wei,3 Qibiao Su,4 Kedao Lai,1 Guining Wei1 1Department of Pharmacology, Key Laboratory of ...
He J   +14 more
doaj  

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