Results 211 to 220 of about 7,322,114 (249)

High dietary inflammatory index (DII) scores increase odds of overweight in adults with rs9939609 polymorphism of FTO gene.

Clinical Nutrition ESPEN, 2021
BACKGROUND Obesity/overweight is a public health problem globally. Dietary induced inflammation is among the most critical risk factors modulating overweight/obesity. Some people genetically are at higher risk for obesity/overweight.
Mahsa Mehrdad, Farhad Vahid, N. Shivappa, J. Hébert, M. Fardaei, Mohammad Hassan Eftekhari   +5 more
semanticscholar   +1 more source

Role of FTO gene polymorphisms in Wilms tumor predisposition: A five‐center case–control study

Journal of Gene Medicine, 2021
Wilms tumor is the most frequently occurring renal malignancy in pediatrics. The FTO gene exhibits a featured genetic contribution to cancer development. Nonetheless, its single nucleotide polymorphism (SNP) contribution to Wilms tumor remains unknown.
Rui-Xi Hua, W. Fu, A. Lin, Haixia Zhou, Jiwen Cheng, Jiao Zhang, Suhong Li, Guochang Liu, H. Xia, Zhenjian Zhuo, Jing He   +10 more
semanticscholar   +1 more source

Association of FTO gene methylation with incident type 2 diabetes mellitus: a nested case-control study.

Gene, 2021
OBJECTIVES This study aimed to investigate the association of FTO methylation level with type 2 diabetes mellitus (T2DM) in a nested case-control study.
Shengbing Huang, P. Qin, Qing Chen, Dongdong Zhang, Cheng Cheng, Chunmei Guo, Quanman Li, Qionggui Zhou, G. Tian, R. Qie, Minghui Han, Xiaoyan Wu, Xingjin Yang, Yifei Feng, Yang Li, Yanyan Zhang, Yuying Wu, Dechen Liu, Jie Lu, M. Zhang, Yang Zhao, D. Hu   +21 more
semanticscholar   +1 more source

Allelic Polymorphism Detected in the Bovine FTO Gene

Molecular Biotechnology, 2011
Studies in humans have independently identified single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene associated with obesity in multiple populations. It was shown that FTO participated in the regulation of energy homeostasis and associated with increased lipolytic activity in adipocytes.
Bao, Zhang, Ya, Zhang, Liangzhi, Zhang, Jing, Wang, Zhuanjian, Li, Hong, Chen   +5 more
openaire   +2 more sources

Association between obesity‐related gene FTO and ADHD

Obesity, 2013
ObjectiveAttention‐deficit/hyperactivity disorder (ADHD) is an etiologically complex heterogeneous behavioral disorder. Several studies have reported that ADHD subjects are more likely to be overweight/obese and that this comorbidity may be due to shared genetic factors.
Zia, Choudhry, Sarojini M, Sengupta, Natalie, Grizenko, Geeta A, Thakur, Marie-Eve, Fortier, Norbert, Schmitz, Ridha, Joober   +6 more
openaire   +2 more sources

Cloning and characterization of chicken fat mass and obesity associated (Fto) gene: fasting affects Fto expression

Domestic Animal Endocrinology, 2012
Fat mass and obesity associated gene (Fto), also known as Fatso, is a member of the Fe-II and 2-oxoglutarate-dependent dioxygenase superfamily. Recent studies in humans and rodents suggest that Fto is involved in food intake regulation and lipid metabolism, whereas single nucleotide mutations in the Fto gene are associated with obesity and type 2 ...
A, Tiwari, S M, Krzysik-Walker, R, Ramachandran   +2 more
openaire   +2 more sources

Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: Insights from in vitro studies using INS-1 cells and human pancreatic islets.

Life Science
AIMS In this study, we investigated the role of the FTO gene in pancreatic β-cell biology and its association with type 2 diabetes (T2D). To address this issue, human pancreatic islets and rat INS-1 (832/13) cells were used to perform gene silencing ...
J. Taneera, Anila Khalique, Sham Abdrabh, A. Mohammed, Amal Bouzid, W. El‐Huneidi, Yasser K. Bustanji, Nabil Sulaiman, Sarah Albasha, M. Saber-Ayad, Mawieh Hamad   +10 more
semanticscholar   +1 more source

Association between FTO gene polymorphisms and breast cancer: the role of estrogen

Expert Review of Endocrinology & Metabolism, 2020
Introduction: The fat mass and obesity-associated (FTO) gene may be associated with breast cancer risk. This study aimed to systematically investigate the association between FTO gene polymorphisms and breast cancer and the possible role of estrogen in ...
M. Gholamalizadeh, A. Jarrahi, M. Akbari, F. Bourbour, Zohreh Mokhtari, Sara Salahshoornezhad, S. Doaei   +6 more
semanticscholar   +1 more source

Influences of FTO gene on onset age of adult overweight

Human Genetics, 2012
FTO affects changes in BMI during both childhood and adulthood. However, its effect on onset age of overweight in adulthood is not known. To address this question, we conducted a study to examine effects of FTO tag SNPs on censored age of overweight in the longitudinal Bogalusa Heart Study (BHS) cohort, which began in 1973-1974.
Hao, Mei, Wei, Chen, Katherine, Mills, Jiang, He, Sathanur R, Srinivasan, Nicholas, Schork, Sarah, Murray, Gerald S, Berenson   +7 more
openaire   +2 more sources

The FTO Obesity Gene. Genotyping and Gene Expression Analysis in Morbidly Obese Patients

Obesity Surgery, 2008
Obesity has emerged as one of the most serious public health concerns in the twenty-first century. the fat mass and obesity associated gene (FTO) has been found to contribute to the risk of obesity in humans. Our aims in this study were to investigate the association of rs9939609 single nucleotide polymorphism (SNP) of the FTO gene with different ...
Carina, Zabena, José L, González-Sánchez, María T, Martínez-Larrad, Antonio, Torres-García, Jesús, Alvarez-Fernández-Represa, Arturo, Corbatón-Anchuelo, Milagros, Pérez-Barba, Manuel, Serrano-Ríos   +7 more
openaire   +2 more sources