Ampicillin-Resistant β-lactamase-negative Haemophilus Influenzae Strains Isolated in the Czech Republic in 2010-2018 [PDF]
Ampicillin-resistant β-lactamase- negative Haemophilus influenzae strains isolated in the Czech Republic in 2010-2018 According to the results of regular surveillance of resistance of bacterial pathogens of respiratory tract infections, the number of ...
Jakubů, Vladislav
core
Fifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and ...
María-José Giménez +2 more
doaj +1 more source
Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley +1 more source
In vivo cell division gene product interactions in Escherichia coli K-12 [PDF]
Overexpression of plasmid-coded PBP 3 was analyzed in strains harboring ftsA, ftsH, pbpB (ftsI), ftsQ, ftsZ, or recA441 (Tif) mutations. Higher cellular levels of PBP 3, the pbpB gene product, could not restore septum formation of ftsA, ftsQ, ftsZ, and ...
Betzner, A. +3 more
core +1 more source
Abstract The elongasome, or the Rod complex, orchestrates lateral peptidoglycan (PG) synthesis in many rod‐shaped bacteria. It consists of the actin‐like protein MreB, the PG synthase RodA‐PBP2 complex, as well as MreCD and RodZ. Although the loss or disruption of any elongasome component results in a loss of rod shape, previous studies found that a ...
Rui Zhan +5 more
wiley +1 more source
A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility
Background Identification and characterization of non-typeable Haemophilus influenzae (NTHi) with reduced susceptibility to β-lactam antibiotics due to mutations in penicillin binding protein 3 (PBP3) is a clinical challenge. We analyzed a blood isolate,
John Thegerström +4 more
doaj +1 more source
ABSTRACT The emergence of cefotaxime‐resistant Haemophilus influenzae (CRHI) in Norway during the 2000s coincided with increased use of oral aminopenicillins and parenteral third‐generation cephalosporins. This study examined associations between beta‐lactam consumption and CRHI incidence. Surveillance data on antibiotic usage across Norwegian regions (
Dagfinn Skaare, Gunnar Skov Simonsen
wiley +1 more source
Cefuroxime resistance in non-β-lactamase Haemophilus influenzae is linked to mutations in ftsI [PDF]
The penicillin binding protein (PBP) genes dacA, dacB and ftsI from 14 cefuroxime-resistant (CXM(R)) isolates and three clinical isolates with low CXM MIC for non-beta-lactamase-producing Haemophilus influenzae type b were molecularly characterized.
Straker, K +5 more
core
SanA Plays a Role in Peptidoglycan Integrity in Escherichia coli
SanA is a novel regulator of peptidoglycan synthesis, potentially through functional interplay with PBP1B‐dependent pathways. ABSTRACT Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In Escherichia coli, peptidoglycan required for cell elongation is synthesized by
Honoka Yamaguchi +6 more
wiley +1 more source
Contribution of ROB-1 and PBP3 mutations to the resistance phenotype of a β-lactamase-positive amoxicillin/clavulanic acid-resistant Haemophilus influenzae carrying plasmid pB1000 in Italy. [PDF]
OBJECTIVES: plasmid pB1000 bearing bla(ROB-1) is responsible for high-level β-lactam resistance in Haemophilus influenzae as well as in Pasteurella multocida and Haemophilus parasuis isolates from Spain.
San Millan, A +7 more
core +1 more source

