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Endothelial viral inclusions in Fuchs' corneal dystrophy
Human Pathology, 1987A case of Fuchs' corneal dystrophy is presented. The patient, a 70-year-old white woman, had bilateral decreasing vision, especially while reading and driving at night. Clinical features were characteristic of Fuchs' corneal dystrophy. Ultrastructural studies demonstrated findings in Descemet's membrane typical of those previously reported with ...
S I, Roth, E L, Stock, R, Jutabha
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The Molecular Basis of Fuchs’ Endothelial Corneal Dystrophy
Molecular Diagnosis & Therapy, 2019Fuchs' endothelial corneal dystrophy (FECD) is a common disease resulting from corneal endothelial cell dysfunction. It is inherited in an autosomal dominant fashion with incomplete penetrance, and with a female bias. Approximately half of cases occur sporadically, and the remainder are familial. Early and late-onset forms of the disease exist.
Jie Zhang +2 more
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Cancer Risk in Patients With Fuchs Endothelial Corneal Dystrophy
Cornea, 2021Purpose: The purpose of this study is to quantify cancer risk in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: Using the 2014 to 2016 Medicare Limited 5% Data Sets—Carrier Line File, US Medicare fee-for-service beneficiaries (aged 65 years or older) with FECD ...
Timothy T. Xu +4 more
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Matrix metalloproteinases and their inhibitors in Fuchs endothelial corneal dystrophy
Experimental Eye Research, 2021Fuchs endothelial corneal dystrophy (FECD) is characterized by a progressive loss of corneal endothelial cells (CECs) and an abnormal accumulation of extracellular matrix in Descemet's membrane leading to increased thickness and formation of excrescences called guttae.
Isabelle Xu +4 more
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Genotyping methods for Fuchs corneal endothelial dystrophy
Journal Français d'OphtalmologieFuchs endothelial corneal dystrophy (FECD) is a genetic degenerative disease characterized by the progressive degradation of the corneal endothelium, often leading to vision loss. It is the leading cause of corneal transplantation in the Western world. FECD is more common in Europe and the United States, particularly among women.
D. Onitiu +9 more
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Diurnal Variation in Corneal Edema in Fuchs Endothelial Corneal Dystrophy
American Journal of Ophthalmology, 2019The extent of diurnal variation in corneal edema in Fuchs dystrophy is unknown. We measured corneal thickness and posterior profile over the course of the day using Scheimpflug imaging.Prospective cohort study.Participants with clinically advanced Fuchs dystrophy eyes undergoing endothelial keratoplasty and participants with healthy corneas were ...
Marianne Fritz +6 more
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Fuchs endothelial corneal dystrophy: an updated review
International OphthalmologyThe present review will summarize FECD-associated genes and pathophysiology, diagnosis, current therapeutic approaches, and future treatment perspectives.Literature review.Fuchs' endothelial corneal dystrophy (FECD) is the most common bilateral corneal dystrophy and accounts for one-third of all corneal transplants performed in the US.
Francisco Altamirano +5 more
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The heterogeneity of Fuchs endothelial corneal dystrophy †
The Journal of PathologyAbstract Late‐onset Fuchs endothelial corneal dystrophy (FECD) is characterized by distinct extracellular matrix deposits (guttae) within the basement membrane (Descemet's membrane) of the corneal endothelium.
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