Fucosylated Chondroitin Sulfate from Bohadschia ocellata: Structure Analysis and Bioactivities
ProcessesFucosylated chondroitin sulfate (FCS) was prepared from Bohadschia ocellata using protease hydrolysis. The structural characteristics of FCS were confirmed through chemical composition analysis using FTIR spectroscopy, 1H NMR, and 13C NMR. FCS from B. ocellata (FCS-Bo) exhibited an average molecular weight of approximately 122 kDa.
Pham Duc Thinh +8 more
openaire +1 more source
PLoS ONE, 2013 Holothurian glycosaminoglycan (hGAG) is a high-molecular-weight form of fucosylated chondroitin sulfate and has an antithrombotic effect. Our previous studies demonstrated that hGAG efficiently inhibited tumor cell metastasis.
Yang Zhao +9 more
doaj +1 more source
Involvement of Nitric Oxide on Bothropoides insularis Venom Biological Effects on Murine Macrophages In Vitro [PDF]
, 2016 Viperidae venom has several local and systemic effects, such as pain, edema, inflammation, kidney failure and coagulopathy. Additionally, bothropic venom and its isolated components directly interfere on cellular metabolism, causing alterations such as ...
de Menezes, Ramon R. P. P. B. +1 more
core +2 more sources
Marine Drugs, 2019 Apostichopus japonicus is one of the most economically important species in sea cucumber aquaculture in China. Fucosylated glycosaminoglycan from A. japonicus (AjFG) has shown multiple pharmacological activities.
Ruowei Guan +9 more
doaj +1 more source
Fucosylated chondroitin sulfate and an heparin analog effect on Plasmodium falciparum cytoadhesion and merozoite invasion [PDF]
, 2018 Orientador: Fabio Trindade Maranhão CostaTese (doutorado) - Universidade Estadual de Campinas, Instituto de BiologiaResumo: Acredita-se que o sequestro de eritrócitos infectados por Plasmodium falciparum (Pf-EIs) na microvasculatura de órgão vitais ...
Bastos, Marcele Fontenelle, 1986
core
Detailed characterization of the O-linked glycosylation of the neuropilin-1 c/MAM-domain [PDF]
, 2016 Neuropilins are involved in angiogenesis and neuronal development. The membrane proximal domain of neuropilin-1, called c or MAM domain based on its sequence conservation, has been implicated in neuropilin oligomerization required for its function. The c/
Altmann, F +3 more
core
P-selectin mediates metastatic progression through binding to sulfatides on tumor cells [PDF]
, 2017 Hematogenous carcinoma metastasis is associated with tumor cell emboli formation, which is now known to be facilitated by selectins. P-selectin-mediated interactions of platelets with cancer cells are based mostly on mucin- and glycosaminoglycan-type ...
Borsig, L., Callewaert, N., Garcia, J.
core
Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures. [PDF]
Glycobiology, 2023 Dwivedi R +6 more
europepmc +1 more source
Towards the semi-synthesis of phosphorylated mimics of glycosaminoglycans: Screening of methods for the regioselective phosphorylation of chondroitin [PDF]
Glycosaminoglycan (GAG) mimics carrying phosphate rather than sulfate anionic groups have been poorly investigated, in spite of their interesting perspectives.
Bedini, Emiliano +3 more
core +1 more source
Characterization of Glycan and Glycoprotein by Mass Spectrometry for Therapeutic Drugs Development and Biomarker [PDF]
, 2020 Glycosylation is an essential post-translational modification of protein, which is involved in many biological processes including protein folding, immune response, protein-protein interaction and pathogens. Glycan exhibits complexity and dynamic changes
Liu, Ding
core +1 more source