Results 211 to 220 of about 13,568 (269)

The polymorphisms of fucosyltransferases

Legal Medicine, 2001
The alpha(1,2)fucosyltransferase Se enzyme regulates the expression of the ABH antigens in secretion. Secretors, who have ABH antigens in their saliva, have at least one functional Se allele in the FUT2 locus, while non-secretors, who fail to express ABH antigens in saliva, are homozygous for the non-functional se allele. Molecular analyses of the FUT2
Y, Koda, M, Soejima, H, Kimura
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Fucosyltransferase (α1,2/ α1,3/ α1,4-fucosyltransferases)

2009
Many studies using monoclonal antibodies have demonstrated that fucosylated carbohydrate chains are involved in various physiological functions including development, neuronal activity, and cancerous transformation. The genes encoding fucosyltransferases which synthesize fucosylated carbohydrate antigens have been cloned, and their function has been ...
Takashi Kudo, Hisashi Narimatsu
openaire   +1 more source

Recent Progress on Fucosyltransferase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2012
Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the ...
Merino, Pedro, Tejero, Tomás, Delso, J. Ignacio, Hurtado-Guerrero, Ramón, Gómez-SanJuan, Asier, Sádaba, David   +5 more
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Cloning of a rat α1,3-fucosyltransferase gene: a member of the fucosyltransferase IV family

Glycoconjugate Journal, 1997
We report the cloning of a rat alpha1,3-fucosyltransferase gene (rFuc-T), isolated from a rat genomic library by a PCR-cross-hybridization based cloning approach using primers derived from the conserved region of human alpha1,3-Fuc-T sequences. Comparison of the rFuc-T predicted amino acid sequence with those of previously cloned human and murine ...
E M, Sajdel-Sulkowska, F I, Smith, G, Wiederschain, R H, McCluer   +3 more
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Evaluation of serum fucosyltransferases in malignancy

European Journal of Cancer and Clinical Oncology, 1984
Incorporation of [14C]-fucose into the endogenous acceptor of serum and into the exogenous acceptors desialofetuin (alpha 2-fucosyltransferase) and desialodegalactofetuin (alpha 3-fucosyltransferase) was determined in controls and in patients with various malignant diseases.
R, Kuzmits, P, Aiginger
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Development of fucosyltransferase and fucosidase inhibitors

Chemical Society Reviews, 2013
L-Fucose-containing glycoconjugates are essential for a myriad of physiological and pathological activities, such as inflammation, bacterial and viral infections, tumor metastasis, and genetic disorders. Fucosyltransferases and fucosidases, the main enzymes involved in the incorporation and cleavage of L-fucose residues, respectively, represent ...
Zhijay, Tu, Yu-Nong, Lin, Chun-Hung, Lin
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Characterization of fucosyltransferase activity during mouse spermatogenesis: evidence for a cell surface fucosyltransferase

Biochemistry, 1989
Fucosyltransferase activity was quantified in mouse germ cells at different stages of spermatogenesis. Specifically, fucosyltransferase activities of pachytene spermatocytes, round spermatids, and cauda epididymal sperm were compared. Fucosyltransferase activity of mixed germ cells displayed an apparent Vmax of 17 pmol (mg of protein)-1 min-1 and an ...
R A, Cardullo, D R, Armant, C F, Millette   +2 more
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Occurrence and specificities of α3-fucosyltransferases

The Histochemical Journal, 1992
The Le(x) (CD15) carbohydrate antigen and sialylated and oligomeric derivatives thereof have been implicated in cell adhesion processes. Expression of these antigens is developmentally regulated and (re)occurrence of several members of this group has been reported in malignant transformation of cells.
T, de Vries, D H, van den Eijnden
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