The contribution of fucosyltransferases to cancer biology [PDF]
Brazilian Journal of BiologyFucosyltransferases are enzymes that transfer L-fucose residues from a donor substrate to target molecules. These enzymes are encoded by genes known as FUTs (FUT1 to FUT-11), along with POFUT1 and 2.
A. O. Vasconcelos +3 more
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AtFUT4 and AtFUT6 Are Arabinofuranose-Specific Fucosyltransferases [PDF]
Frontiers in Plant Science, 2021 The bulk of plant biomass is comprised of plant cell walls, which are complex polymeric networks, composed of diverse polysaccharides, proteins, polyphenolics, and hydroxyproline-rich glycoproteins (HRGPs).
Maria J. Soto +28 more
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Neuraminidase of influenza A viruses induces global desialylation of host cells via its intracellular function [PDF]
Microbiology SpectrumThe neuraminidase protein (NA) of influenza A viruses (IAVs) plays a role in the release of viruses from infected cells. NA on viral particles hydrolyzes sialylated glycans on the cell surface for viral budding.
Daiki Kobayashi +3 more
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The ABC type fucose operon regulated by XtrSs through CcpA contributes to Streptococcus suis survival in macrophages [PDF]
VirulenceStreptococcus suis (S. suis), an important zoonotic pathogen, poses a huge threat to the pig industry and human health. The fucose operon (FCS) is found in many bacteria that utilize host glycosylation modifications, contributing to bacterial growth and ...
Song Liang +8 more
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Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation [PDF]
Genes and DiseasesFucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Caihan Duan +4 more
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Altered O-linked glycosylation in benign and malignant meningiomas [PDF]
PeerJBackground Changes in protein glycosylation have been reported in various diseases, including cancer; however, the consequences of altered glycosylation in meningiomas remains undefined.
Chutima Talabnin +7 more
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Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]
Nature CommunicationsCore fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang +7 more
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A new superfamily of protein-O-fucosyltransferases, 2-fucosyltransferases, and 6-fucosyltransferases: phylogeny and identification of conserved peptide motifs [PDF]
Glycobiology, 2003 The presence of three conserved peptide motifs shared by alpha2-fucosyltransferases, alpha6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by ...
Ivan Martínez-Duncker +2 more
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Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages [PDF]
IMA Fungus, 2023 Fucose is a deoxyhexose sugar present and studied in mammals. The process of fucosylation has been the primary focus in studies relating to fucose in animals due to the presence of fucose in Lewis antigens.
Małgorzata Orłowska +3 more
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Structure, function, and implications of fucosyltransferases in health and disease [PDF]
Nature CommunicationsFucosylation is a ubiquitous glycosylation event that shapes cellular communication and immunity. Catalyzed by fucosyltransferases (FUTs), this reaction encompasses diverse substrates, mechanisms, and biologic consequences. In this Review, we explore the
Mattia Ghirardello +5 more
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