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The Contribution of Fucosyltransferases to Cancer Biology [PDF]
Brazilian Journal of BiologyFucosyltransferases are enzymes that transfer L-fucose residues from a donor substrate to target molecules. These enzymes are encoded by genes known as FUTs (FUT1 to FUT-11), along with POFUT1 and 2.
Anderson Vasconcelos +2 more
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AtFUT4 and AtFUT6 Are Arabinofuranose-Specific Fucosyltransferases [PDF]
Frontiers in Plant Science, 2021 The bulk of plant biomass is comprised of plant cell walls, which are complex polymeric networks, composed of diverse polysaccharides, proteins, polyphenolics, and hydroxyproline-rich glycoproteins (HRGPs).
Maria J. Soto +28 more
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Journal of Inflammation Research, 2023 Pengfei Wang,1,2,* Xuxu Liu,1,2,* Jingjing Yu,1,2 Ziang Meng,1,2 Zhenyi Lv,1,2 Ce Shang,1,2 Qi Geng,1,2 Dawei Wang,1,2 Dongbo Xue,1,2 Long Li3 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin ...
Dongbo Xue, Zhenyi Lv, Jingjing Yu
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Acute and chronic lung inflammation drives changes in epithelial glycans [PDF]
Frontiers in Immunology, 2023 IntroductionAsthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally referring to collagen deposition and epithelial hyperplasia.
Carlos A. Alvarez +6 more
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Structural Insights in Mammalian Sialyltransferases and Fucosyltransferases: We Have Come a Long Way, but It Is Still a Long Way Down [PDF]
Molecules, 2021 Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive ...
Ravneet Kaur Grewal +6 more
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Viruses, 2023 Although rotavirus A (RVA) is the primary cause of acute viral gastroenteritis in children and young animals, mechanisms of its replication and pathogenesis remain poorly understood.
Molly Raque +5 more
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Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma [PDF]
International Journal of Molecular and Cellular Medicine, 2021 Aberrant protein glycosylation is known to be associated with the development of various cancers. Although fucosylation is essential for normal biological functions, alterations in fucosylation are strongly implicated in cancer and increasing metastatic ...
Kruti Mehta +3 more
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FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway
BMC Pulmonary Medicine, 2023 Objective Fucosyltransferases (FUTs) molecules have been identified to be involved in carcinogenesis of malignant tumors. Nevertheless, the biological function of fucosyltransferases-3 (FUT3) in lung adenocarcinoma (LUAD) malignant phenotype remains ...
Lanlan Lin +5 more
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Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Kim van Noort +6 more
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Frontiers in Oncology, 2018 Aberrant glycosylation of tumor cells is recognized as a universal hallmark of cancer pathogenesis. Overexpression of fucosylated epitopes, such as type I (H1, Lewisa, Lewisb, and sialyl Lewisa) and type II (H2, Lewisx, Lewisy, and sialyl Lewisx) Lewis ...
Athanasios Blanas +4 more
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