Results 1 to 10 of about 9,953 (128)

Fucose metabolism as a central axis linking inflammation, immunity, and cancer in the gut [PDF]

Frontiers in Immunology
Fucose metabolism and fucosylation are emerging as central regulators of intestinal epithelial integrity, immune homeostasis, host-microbiota interactions, and tumor progression.
Dhirendra K. Singh, Chieko Saito, Yukihiro Yamaguchi, Olivia G. Cassidy, Keita Nishiyama, Lei Huang   +5 more
doaj   +2 more sources

Fucosylation Dynamics as a Critical Determinant of Cancer Cell Fate in Colorectal Carcinoma: Integrating Hallmark Plasticity, Microenvironmental Remodelling, and Therapeutic Resistance [PDF]

Biology
Fucosylation, the enzymatic addition of fucose residues to glycans, modulates receptor signalling and cellular identity in the intestinal epithelium. Its role as an integrative determinant of cancer cell fate in colorectal cancer (CRC) remains undefined.
Abdulaziz Alfahed, Abdulrahman A. Alahmari, Glowi Alasiri   +2 more
doaj   +2 more sources

Fucosylated hemocyanin regulates ER stress to enhance shrimp antibacterial immunity [PDF]

Virulence
Invertebrates rely on post-translational modifications (PTMs) of immune effectors to regulate innate immunity, yet how hemocyanin fucosylation mediates intracellular antimicrobial signaling remains a critical knowledge gap in crustacean immunology ...
Mingming Jiang, Junyang Zhou, Xinyue Ren, Yiqi Liu, Jiawei Cheng, Yueling Zhang, Zhihong Zheng   +6 more
doaj   +2 more sources

Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia [PDF]

Nature Communications
Preeclampsia (PE) is a severe pregnancy disorder caused by placental dysfunction. Protein O-fucosylation is a type of protein post translational modification that is catalyzed by protein O-fucosyltransferases (poFUTs).
Yaqi Li, Hongpan Wu, Yuyu Lei, Shuyu Bai, Jiao Wang, Bin Yan, Yubo Liu, Shuai Liu   +7 more
doaj   +2 more sources

FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease [PDF]

Frontiers in Microbiology
Intestinal fucosylation, the enzymatic addition of fucose to glycoconjugates, represents a pivotal regulatory mechanism that modulates host–microbiota crosstalk in the gastrointestinal tract.
Lifen Zhao, Nianzhu Zhang
doaj   +2 more sources

Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation

Genes and Diseases
Fucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Xiaohua Hou, Chaoqun Han, Caihan Duan
exaly   +3 more sources

The Function of Fucosylation in Progression of Lung Cancer

Frontiers in Oncology, 2018
Lung cancer is a disease that influences human health and has become a leading cause of cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage.
Jihong Cui, Tianran Ma, Liyuan Jia
exaly   +3 more sources

Intestinal neutral ceramidase exacerbates MASH pathogenesis [PDF]

eGastroenterology
Background Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration.
Chao Lei, Ting Wang, Liang Chen, Xiang Zhang, Jing Feng, Zhongbin Deng, Craig J McClain, Xiaotong Song, Amanguli Tuohongerbieke, Regina Gasparetto, Yi Tan   +10 more
doaj   +2 more sources

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]

PLoS Pathogens
Understanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun, Yixin Xiang, Yichen Yang, Yubei Tan, Zhelin Su, Zhen Fu, Yanan Fu, Shengsong Xie, Guiqing Peng   +8 more
doaj   +2 more sources

Core fucosylation regulates the ovarian response via FSH receptor during follicular development

Journal of Advanced Research
Introduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Naoyuki Taniguchi, Tomohiko Fukuda, Jianguo Gu   +2 more
exaly   +3 more sources