Fucosylation Dynamics as a Critical Determinant of Cancer Cell Fate in Colorectal Carcinoma: Integrating Hallmark Plasticity, Microenvironmental Remodelling, and Therapeutic Resistance [PDF]
BiologyFucosylation, the enzymatic addition of fucose residues to glycans, modulates receptor signalling and cellular identity in the intestinal epithelium. Its role as an integrative determinant of cancer cell fate in colorectal cancer (CRC) remains undefined.
Abdulaziz Alfahed +2 more
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Frontiers in Microbiology, 2020 The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Wenzhe Li, , Tomohiko Fukuda
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Cells, 2023 Various tumors rely on post-translational modifications (PTMs) to promote invasiveness and angiogenesis and to reprogram cellular energetics to abate anti-cancer immunity.
Carmen Criscitiello +2 more
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FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]
PLoS PathogensUnderstanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun +8 more
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Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity
Frontiers in Immunology, 2022 Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Wenzhe Li, Li Wenzhe
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Genes and DiseasesFucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Xiaohua Hou, Chaoqun Han, Caihan Duan
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FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation [PDF]
Cell Communication and SignalingBackground The pathogenesis of psoriasis is characterized by dysregulated post-translational modifications, with particular emphasis on fucosylation—a glycosylation process mediated by fucosyltransferases (FUTs).
Xia Li +8 more
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Core fucosylation regulates the ovarian response via FSH receptor during follicular development
Journal of Advanced ResearchIntroduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Naoyuki Taniguchi +2 more
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FUT3 mediated GRP78 fucosylation promotes colorectal cancer survival and proliferation under glucose restriction via PERK/ATF4/STC2 axis [PDF]
npj Precision OncologyTumor competition for nutrients within the microenvironment triggers stress responses to adapt to adverse conditions; however, the mechanism by which a glucose-depleted environment influences tumor fucosylation to promote endoplasmic reticulum (ER ...
Kaiwen Qin +15 more
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Advances and challenges in plant N-glycoengineering: when fucosylation matters [PDF]
Frontiers in Plant SciencePlant-based expression systems have emerged as promising platforms to produce recombinant glycoproteins. Transient recombinant protein production is a promising alternative to stable transgenic systems, particularly for emergency situations in which ...
Kavya Gauba +2 more
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