Results 41 to 50 of about 12,499 (209)

Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

Cell Reports, 2023
Summary: As highly organized consortia of bacteria, biofilms have long been implicated in aggravating inflammation. However, our understanding regarding in vivo host-biofilm interactions in the complex tissue environments remains limited. Here, we show a
Xue-Kun Guo, Jiali Wang, Vincent P. van Hensbergen, Jintao Liu, Huji Xu, Xiaoyu Hu   +5 more
doaj   +1 more source

Aberrant Fucosylation of Saliva Glycoprotein Defining Lung Adenocarcinomas Malignancy

, 2022
Aberrant glycosylation is a hallmark of cancer found during tumorigenesis and tumor progression. Lung cancer (LC) induced by oncogene mutations has been detected in the patient’s saliva, and saliva glycosylation has been altered.
Mingming Xu (649152), Xumin Zhang (698351), Piliang Hao (230313), Ziyuan Gao (12567140), Junhong Jiang (12177086), Jun Xia (135528), Shuang Yang (64650), Ying Han (137520), Shuwei Li (1345710), Zhen Wu (358187), Shan Huang (282228)   +10 more
core   +1 more source

O-fucosylation of CCN1 is required for its secretion [PDF]

, 2015
The matricellular protein CCN1, also known as Cyr61, is a secreted ligand and has numerous functions. Human CCN1 contains one predicted O-fucosylation site in the thrombospondin type-1 repeat (TSR1) domain at Thr242.
Simizu, Siro, Suzuki, Takehiro, Dohmae, Naoshi, Niwa, Yuki   +3 more
core   +1 more source

Immunoassay for quantification of antigen-specific IgG fucosylation [PDF]

, 2022
BACKGROUND: Immunoglobulin G (IgG) antibodies serve a crucial immuno-protective function mediated by IgG Fc receptors (FcγR). Absence of fucose on the highly conserved N-linked glycan in the IgG Fc domain strongly enhances IgG binding and activation of ...
Larsen, Mads Delbo, Derksen, N.I.L., Esch, W.J.E. van, Larsen, M.D., van Esch, Wim J.E., Wang, Wenjun, Schoot, C.E. van der, Rebergen, Ianthe, Linty, F., van de Watering, Leo, Damelang, Timon, de Taeye, Steven W., Nouta, J., Watering, L. van de, Coillie, J. van, Gils, M.J. van, Wang, W.J., Geerdes, Dionne M, Taeye, S.W. de, Wuhrer, Manfred, Afd Biomol.Mass Spect. and Proteomics, Szittner, Z., Geerdes, Dionne M., Derksen, Ninotska I.L., Nouta, Jan, Rispens, Theo, Derksen, Ninotska I. L., Sustic, T., Rebergen, I., Szittner, Zoltan, Rispens, T., Visser, Remco, van Esch, Wim J. E., Šuštić, Tonći, de Taeye, Steven W, van Gils, Marit J., Mok, J.Y., Wuhrer, M., van Esch, Wim J E, van Gils, Marit J, Linty, Federica, Van Coillie, Julie, Mok, Juk Yee, Derksen, Ninotska I L, van der Schoot, C Ellen, Biomolecular Mass Spectrometry and Proteomics, van der Schoot, C. Ellen, Geerdes, D.M., Visser, R., Vidarsson, G., Damelang, T., Vidarsson, Gestur   +51 more
core   +2 more sources

‐catalyzed core fucosylation in Alzheimer's amyloid‐β oligomer‐induced activation of human microglia [PDF]

, 2023
Fucosylation, especially core fucosylation of N-glycans catalyzed by α1-6 fucosyltransferase (fucosyltransferase 8 or FUT8), plays an important role in regulating the peripheral immune system and inflammation.
Mendiola, Ulises Ruiz, Maezawa, Izumi, Carlito B. Lebrilla, Jacopo di Lucente, Tang, Xinyu, Angela M. Zivkovic, Lee‐Way Jin, Lebrilla, Carlito B, di Lucente, Jacopo, Zivkovic, Angela M, Ulises Ruiz Mendiola, Izumi Maezawa, Xinyu Tang, Jin, Lee‐Way   +13 more
core   +1 more source

Analysis of Xyloglucan Fucosylation in Arabidopsis

Plant Physiology, 2003
AbstractXyloglucan (XyG) is a load-bearing primary wall component in dicotyledonous and non-graminaceous monocotyledonous plants. XyG fucosyltransferase (FUTase), encoded by the Arabidopsis gene AtFUT1, directs addition of fucose (Fuc) residues to terminal galactose residues on XyG side chains.
Robyn M, Perrin, Zhonghua, Jia, Tanya A, Wagner, Malcolm A, O'Neill, Rodrigo, Sarria, William S, York, Natasha V, Raikhel, Kenneth, Keegstra   +7 more
openaire   +3 more sources

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Enzymatic fucosylation of oligosaccharides [PDF]

, 2021
Fucosylated oligosaccharides occur naturally in the mammalian body, for example in the form of blood group antigens or human milk oligosaccharides. Human milk oligosaccharides act as inhibitors of pathogen binding to infantile gastrointestinal epithelial
Horáčková, Karolína
core  

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science
The growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2‐fucosylation‐enhancing strategies shows significant potential as a colitis ...
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
doaj   +1 more source

IgG Fucosylation: An Emerging Key Player in the Treatment of Severe COVID-19

Engineering
Protein glycosylation is one of the most vital modifications. Understanding the role of protein glycosylation in coronavirus disease 2019 (COVID-19) is the key in elucidating its pathogenesis and developing therapeutic strategies.
Caiping Zhao, Jingrong Wang, Yuan Liu, Baoling Shang, Danna Lin, Yao Xiao, Hong Ren, Yue Li, Wen Rui, Xu Zou, Hudan Pan, Liang Liu   +11 more
doaj   +1 more source