Results 41 to 50 of about 13,321 (212)

Fruitfly fucosylation [PDF]

Genome Biology, 2002
A biocomputational study of the fruitfly genome reveals the presence of new genes putatively involved in ...
openaire   +1 more source

The Function of Fucosylation in Progression of Lung Cancer

Frontiers in Oncology, 2018
Lung cancer is a disease that influences human health and has become a leading cause of cancer mortality worldwide. However, it is frequently diagnosed at the advanced stage.
Liyuan Jia, Jing Zhang, Tianran Ma, Yayuan Guo, Yuan Yu, Yuan Yu, Yuan Yu, Jihong Cui, Jihong Cui, Jihong Cui   +9 more
doaj   +1 more source

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Aging and Disease, 2023
Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease with unclear underlying molecular mechanisms and limited therapeutic options.
Wen Zhang, Wenchao Lin, Xiaofang Zeng, Men-Qiu Zhang, Qin Chen, Yiyang Tang, Jing Sun, Benhui Liang, Lihuang Zha, Zaixin Yu   +9 more
semanticscholar   +1 more source

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Nature Communications
Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it’s unclear whether homologous recombination (HR) status-dependent glycosylation can be therapeutically explored.
Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, T. Yang, Yuan Qi, Toshitha Kannan, Andrew V Kossenkov, Hiroaki Tateno, Daniel T. Claiborne, Nan Zhang, M. Abdel-Mohsen, Rugang Zhang   +18 more
semanticscholar   +1 more source

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

Nature Communications
Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis.
Qiu Pan, Yan Xie, Ying Zhang, Xinqi Guo, Jing Wang, Min Liu, Xiao-Lian Zhang   +6 more
semanticscholar   +1 more source

Cell wall fucosylation in Arabidopsis influences control of leaf water loss and alters stomatal development and mechanical properties

Journal of Experimental Botany, 2023
The Arabidopsis sensitive-to-freezing8 (sfr8) mutant exhibits reduced cell wall (CW) fucose levels and compromised freezing tolerance. To examine whether CW fucosylation also affects the response to desiccation, we tested the effect of leaf excision in ...
Paige E Panter, Jacob Seifert, M. Dale, Ashley J. Pridgeon, Rachel Hulme, Nathan Ramsay, S. Contera, H. Knight   +7 more
semanticscholar   +1 more source

Fucose metabolism as a central axis linking inflammation, immunity, and cancer in the gut

Frontiers in Immunology
Fucose metabolism and fucosylation are emerging as central regulators of intestinal epithelial integrity, immune homeostasis, host-microbiota interactions, and tumor progression.
Dhirendra K. Singh, Chieko Saito, Yukihiro Yamaguchi, Olivia G. Cassidy, Keita Nishiyama, Lei Huang   +5 more
doaj   +1 more source

Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice

Journal of Microbiology, Immunology and Infection, 2021
Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid, Nianzhu Zhang, Hui Fang, Jianguo Gu, Ming Li, Wenzhe Li   +5 more
doaj   +1 more source

Glucose deprivation induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.

Journal of Clinical Investigation, 2021
Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic effects of such stresses by inducing molecular adaptations that promote clonal selection of a ...
Jane Loong, T. Wong, M. Tong, Rakesh Sharma, Lei Zhou, K. Ng, H. Yu, C. Li, K. Man, C. Lo, X. Guan, Terence K. Lee, J. Yun, Stephanie Ma   +13 more
semanticscholar   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source