Results 51 to 60 of about 10,058 (125)

Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population

Allergy, EarlyView.
The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard, Ralph Heijmans, Virgil A. S. H. Dalm, Silvan Licher, Jan Nouta, Steinar Gijze, David Falck, P. Martin van Hagen, Robin Peeters, Manfred Wuhrer, Layal Chaker   +10 more
wiley   +1 more source

Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation

Scientific Reports, 2017
Glycosylation of uterine endometrial cells plays important roles to determine their receptive function to blastocysts. Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to ...
Ming Yu, Jiao Wang, Shuai Liu, Xiaoqi Wang, Qiu Yan   +4 more
doaj   +1 more source

A guide to host genetic determinants of female microbiome composition across distinct anatomical niches

The FEBS Journal, EarlyView.
Host genetic variation in immune regulation and cell signalling genes was associated with microbiome composition across vaginal, gut, oral and skin sites, while associations involving metabolic function, epithelial barrier integrity and hormonal processes were more site‐specific. Overall, our findings indicate that host genetic variation contributes to
Isabella Margaret Davidson, Elham Nikbakht, Hayley O'Neill, Larisa Margaret Haupt, Paul Joseph Dunn   +4 more
wiley   +1 more source

DNA‐Barcoded Polysaccharide Specific Monoclonal Antibodies Facilitate Sensitive and Multiplexed Detection of Cell Wall Polymers

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant cell walls are polysaccharide‐rich extracellular matrices composed of multiple complex carbohydrate polymer networks, including cellulose, hemicelluloses, pectins, and glycosylated proteins. Polysaccharide deposition critically impacts cell wall structure, and structural microheterogeneity within cell wall glycans also influences polymer
C. Frankie Griffith, Michael G. Hahn, Ian S. Wallace   +2 more
wiley   +1 more source

Fucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies

Transfusion, EarlyView.
Abstract Background Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).
Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson   +33 more
wiley   +1 more source

Protocols for Assessing Storage Stability and Solubility of Released N‐Linked Glycans Prior to Mass Spectrometry Analysis

Current Protocols, Volume 6, Issue 11, November 2026.
Abstract Released N‐linked glycans are frequently stored between enzymatic release, cleanup, and LC–MS analysis, yet storage solvent and freeze–thaw handling are often reported incompletely or omitted. This unit provides a procedure for determining, within a given laboratory and for a given glycan preparation, whether a selected storage condition ...
Oluwaseun O. Ajayi, Tunde A. Aduloju
wiley   +1 more source

Protein O-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals

Molecules
Domain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage.
Huilin Hao, Benjamin M. Eberand, Mark Larance, Robert S. Haltiwanger   +3 more
doaj   +1 more source

Encoding Cell‐Surface Receptor Function Through Glycosylation: Lessons From CD44

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
CD44 function is not solely determined by its protein sequence, it is dynamically encoded by its glycosylation state. Glycan remodeling generates distinct functional receptor states that regulate ligand recognition, receptor organization, lectin interactions, and signaling.
María Payá‐García, José Manuel Rojas‐Marcos, Iris A. Bermejo, Diego Del Balzo, Ana Ardá, Luca Unione, Jesús Jiménez‐Barbero, Ana Gimeno   +7 more
wiley   +1 more source

Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

Frontiers in Immunology, 2018
CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang, Shanshan Mao, Shijie Sun, Ming Li, Zhi Li, Rui Yu, Tonghui Ma, Jianguo Gu, Jianing Zhang, Naoyuki Taniguchi, Wenzhe Li   +10 more
doaj   +1 more source

Exploring fucosylation in lung cancer: Mechanisms, diagnosis, and therapeutic strategies

Advances in Biomarker Sciences and Technology
Lung cancer remains a global health crisis, responsible for significant morbidity and mortality. Late-stage diagnosis often limits treatment options and patient survival.
Saima Rafique, Wei Ge, Ziyuan Gao, Yan Chen, Jun Xia, Junhong Jiang, Shuang Yang   +6 more
doaj   +1 more source