Results 51 to 60 of about 13,321 (212)

Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation

Nature Communications
Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mechanisms ...
Qian Liu, Emma Adhikari, Daniel K. Lester, Bin Fang, Joseph Johnson, Yijun Tian, Andrea T Mockabee-Macias, V. Izumi, Kelly M. Guzman, M. White, J. Koomen, J. Wargo, Jane L. Messina, Jianfei Qi, Eric K. Lau   +14 more
semanticscholar   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science
The growing incidence of inflammatory bowel diseases, including colitis and Crohn's disease, poses a critical challenge for global healthcare. Current development of α1,2‐fucosylation‐enhancing strategies shows significant potential as a colitis ...
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
doaj   +1 more source

IgG Fucosylation: An Emerging Key Player in the Treatment of Severe COVID-19

Engineering
Protein glycosylation is one of the most vital modifications. Understanding the role of protein glycosylation in coronavirus disease 2019 (COVID-19) is the key in elucidating its pathogenesis and developing therapeutic strategies.
Caiping Zhao, Jingrong Wang, Yuan Liu, Baoling Shang, Danna Lin, Yao Xiao, Hong Ren, Yue Li, Wen Rui, Xu Zou, Hudan Pan, Liang Liu   +11 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Holothurian Fucosylated Chondroitin Sulfate [PDF]

Marine Drugs, 2014
Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates.
openaire   +3 more sources

Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis

Nature Communications, 2022
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins in physiological and pathological processes. However, quantitative characterization of core fucosylation remains challenging due to the complexity and ...
Liwei Cao, T. Lih, Yingwei Hu, M. Schnaubelt, Shao-Yung Chen, Yangying Zhou, Chuanyu Guo, M. Dong, Weiming Yang, R. V. Eguez, Lijun Chen, David J. Clark, Akrit Sodhi, Q. K. Li, Hui Zhang   +14 more
semanticscholar   +1 more source

Abnormal B cell glycosylation in autoimmunity: A new potential treatment strategy

Frontiers in Immunology, 2022
Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) are two autoimmune diseases characterised by the production of pathogenic autoreactive antibodies. Their aetiology is poorly understood. Nevertheless, they have been shown to involve
Marie Morel, Pierre Pochard, Pierre Pochard, Wiam Echchih, Maryvonne Dueymes, Maryvonne Dueymes, Cristina Bagacean, Cristina Bagacean, Sandrine Jousse-Joulin, Sandrine Jousse-Joulin, Valérie Devauchelle-Pensec, Valérie Devauchelle-Pensec, Divi Cornec, Divi Cornec, Christophe Jamin, Christophe Jamin, Jacques-Olivier Pers, Jacques-Olivier Pers, Anne Bordron   +18 more
doaj   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

The Role of Glycosylation in Melanoma Progression

Cells, 2021
Malignant melanoma is the most aggressive form of skin cancer, which originates from the malignant transformation of melanocytes, the melanin-producing cells of the skin.
Chiara De Vellis, Silvia Pietrobono, Barbara Stecca   +2 more
doaj   +1 more source

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora, Chen‐Lin Hsieh, Sanne Schoffelen, Johnny Arnsdorf, Eric A. Toth, Abdul S. Yunus, Thomas E. Cleveland IV, Sara Petersen Bjørn, Mina Ying Min Wu, Noel G. McElvaney, Bjørn Gunnar Rude Voldborg, Thomas R. Fuerst, Nathan E. Lewis   +12 more
wiley   +1 more source