Results 51 to 60 of about 12,499 (209)
Biotechnology and Bioengineering, EarlyView.ABSTRACT Monoclonal antibody (mAb) glycosylation is a critical quality attribute that is difficult to rationally engineer and rapidly assess during cell line development. Here, we investigate whether cell‐surface glycosylation can serve as a surrogate readout of mAb product glycosylation following targeted glycogene engineering in CHO cells.
Cristina Abascal Ruiz +6 more
wiley +1 more source
Abnormal B cell glycosylation in autoimmunity: A new potential treatment strategy
Frontiers in Immunology, 2022 Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) are two autoimmune diseases characterised by the production of pathogenic autoreactive antibodies. Their aetiology is poorly understood. Nevertheless, they have been shown to involve
Marie Morel +18 more
doaj +1 more source
BMEMat, EarlyView.This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang +7 more
wiley +1 more source
Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish [PDF]
, 2014 L-fucose, a monosaccharide widely distributed in eukaryotes and certain bacteria, is a determinant of many functional glycans that play central roles in numerous biological processes. The molecular mechanism, however, by which fucosylation mediates these
Marlow, Florence L. +3 more
core +1 more source
The Role of Glycosylation in Melanoma Progression
Cells, 2021 Malignant melanoma is the most aggressive form of skin cancer, which originates from the malignant transformation of melanocytes, the melanin-producing cells of the skin.
Chiara De Vellis +2 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
Holothurian Fucosylated Chondroitin Sulfate [PDF]
Marine Drugs, 2014 Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates.
openaire +3 more sources
Disease Models & Mechanisms, 2022 Candida infections constitute a blind spot in global public health as very few new anti-fungal drugs are being developed. Genetic surveys of host susceptibilities to such infections using mammalian models have certain disadvantages in that obtaining ...
Marcus T. Glittenberg +3 more
doaj +1 more source
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
High Throughput Screening Tools to Probe and Inhibit Core Fucosylation [PDF]
, 2021 We report a chemo-enzymatic transglycosylation synthesis of the 4-methylumbelliferyl glycoside of a complex-type oligosaccharide substrate for core fucosylation.
Soroko, Maxim
core +1 more source