Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity [PDF]
Frontiers in Immunology, 2022 Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Yuhan Sun +4 more
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FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]
PLoS PathogensUnderstanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun +8 more
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Lactobacillus spp. create a protective micro-ecological environment through regulating the core fucosylation of vaginal epithelial cells against cervical cancer [PDF]
Cell Death and Disease, 2021 Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal epithelial cells is closely related to microbial colonization, and play an important role in protecting the vaginal mucosal epithelial cells. However, no reports
Qingjie Fan +10 more
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Characterization of core fucosylation via sequential enzymatic treatments of intact glycopeptides and mass spectrometry analysis [PDF]
Nature Communications, 2022 Core fucosylation of N-linked glycoproteins has been linked to physiological and pathological processes. Here, the authors develop a mass spectrometry-based method that utilizes Endo F3 followed by PNGase F treatment to quantify site-specific ...
Liwei Cao +14 more
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Core fucosylation regulates the ovarian response via FSH receptor during follicular development [PDF]
Journal of Advanced ResearchIntroduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Tiantong Wang +9 more
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Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota [PDF]
Frontiers in Microbiology, 2020 The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao +8 more
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Liver cancer derived high core fucosylation sEV elict malignancy by activating PI3K/AKT signaling pathway [PDF]
Cell Communication and SignalingSmall extracellular vesicles (sEV) play a key role in liver cancer (LC) by supporting cancer cell survival, local invasion, and distant metastasis.
Zhuo Li +12 more
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Roles of core fucosylation modification in immune system and diseases [PDF]
Cell InsightCore fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals.
Qiu Pan, Xiao-Lian Zhang
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Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility [PDF]
Communications Biology, 2023 Classical and accelerated molecular dynamics simulations reveal how core fucosylation in the IgG1 Fc glycan and the light chain isotype modulate the conformational behavior of the hinge and Fab domains and dynamics of IgG1 antibodies.
Simona Saporiti +11 more
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Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies [PDF]
Frontiers in Immunology, 2022 The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly enhances the efficacy of antibody dependent cellular cytotoxicity (ADCC)
Josée Golay +2 more
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