Roles of core fucosylation modification in immune system and diseases [PDF]
Cell InsightCore fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals.
Qiu Pan, Xiao-Lian Zhang
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Role of Fc Core Fucosylation in the Effector Function of IgG1 Antibodies [PDF]
Frontiers in Immunology, 2022 The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly enhances the efficacy of antibody dependent cellular cytotoxicity (ADCC)
Josée Golay +2 more
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Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation [PDF]
Frontiers in Immunology, 2018 CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang +10 more
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Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity [PDF]
Frontiers in Immunology, 2022 Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Yuhan Sun +4 more
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Core fucosylation regulates the ovarian response via FSH receptor during follicular development [PDF]
Journal of Advanced ResearchIntroduction: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.
Tiantong Wang +9 more
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Quantitative Assessment of Core Fucosylation for Congenital Disorders of Glycosylation. [PDF]
Mass Spectrom (Tokyo)Congenital disorders of glycosylation (CDG) include a group of diseases characterized by defects of N-glycan fucosylation. The analytical molecule of choice for the diagnosis of CDG affecting N-glycosylation is serum transferrin: approximately 10% of the glycans attached to transferrin are fucosylated via an α1,6 linkage at the innermost N ...
Wada Y, Kadoya M.
europepmc +4 more sources
Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression [PDF]
Renal Failure, 2021 Objective Peritoneal fibrosis (PF) ultimately causes ultrafiltration failure and peritoneal dialysis (PD) termination, but there are few effective therapies for it.
Changqing Yu +6 more
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Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility [PDF]
Communications Biology, 2023 Classical and accelerated molecular dynamics simulations reveal how core fucosylation in the IgG1 Fc glycan and the light chain isotype modulate the conformational behavior of the hinge and Fab domains and dynamics of IgG1 antibodies.
Simona Saporiti +11 more
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Core fucosylation and its roles in gastrointestinal glycoimmunology. [PDF]
World J Gastrointest Oncol, 2023 Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis ...
Zhang NZ +7 more
europepmc +3 more sources
Core fucosylation of IL-2RB is required for natural killer cell homeostasis
Cell ReportsSummary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz +14 more
doaj +5 more sources