Results 41 to 50 of about 6,100 (143)

Divergent Chemoenzymatic Synthesis of Asymmetrical‐Core‐Fucosylated and Core‐Unmodified N‐Glycans [PDF]

Chemistry – A European Journal, 2016
AbstractA divergent chemoenzymaytic approach for the preparation of core‐fucosylated and core‐unmodified asymmetrical N‐glycans from a common advances precursor is described. An undecasaccharide was synthesized by sequential chemical glycosylations of an orthogonally protected core fucosylated hexasaccharide that is common to all mammalian core ...
Tiehai Li, Min Huang, Lin Liu, Shuo Wang, Kelley W. Moremen, Geert‐Jan Boons   +5 more
openaire   +3 more sources

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Core fucosylation is required for midline patterning during zebrafish development [PDF]

Developmental Dynamics, 2010
AbstractComplex carbohydrates represent one of the most polymorphic classes of macromolecules, but their functions during embryonic development remain poorly defined. Herein, we show that knockdown of FucT8, the fucosyltransferase responsible for adding an α1,6 fucosyl residue to the core region of N‐linked oligosaccharides, results in defective ...
Anandita, Seth, Quentin J, Machingo, Andreas, Fritz, Barry D, Shur   +3 more
openaire   +2 more sources

Profiling of core fucosylated N-glycans using a novel bacterial lectin that specifically recognizes α1,6 fucosylated chitobiose [PDF]

Scientific Reports, 2016
AbstractA novel fucose-binding lectin (SL2-1) from the bacterium Streptomyces rapamycinicus was identified by analysis of metagenomic DNA sequences. SL2-1 belongs to a new group of bacterial fucose-specific lectins that have no similarity to known bacterial fucose-binding proteins, but are related to certain eukaryotic fucose-binding lectins.
Saulius Vainauskas, Rebecca M. Duke, James McFarland, Colleen McClung, Cristian Ruse, Christopher H. Taron   +5 more
openaire   +2 more sources

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Cell Reports, 2017
Summary: Programmed cell death 1 (PD-1) is highly expressed on exhausted T cells and inhibits T cell activation. Antibodies that block the interaction between PD-1 and its ligand prevent this inhibitory signal and reverse T cell dysfunction, providing ...
Masahiro Okada, Shunsuke Chikuma, Taisuke Kondo, Sana Hibino, Hiroaki Machiyama, Tadashi Yokosuka, Miyako Nakano, Akihiko Yoshimura   +7 more
doaj   +1 more source

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +1 more source

Core fucosylation and IgG function in NAIT

Blood, 2014
In this issue of Blood, Kapur et al show that maternal human platelet-specific antigen 1a (HPA 1a)-specific antibodies causing neonatal alloimmune thrombocytopenia (NAIT) possess oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fucosylated antibodies in promoting phagocytosis of antibody-coated ...
openaire   +3 more sources

Recognition of Complex Core‐Fucosylated N‐Glycans by a Mini Lectin

Angewandte Chemie, 2018
AbstractThe mini fungal lectin PhoSL was recombinantly produced and characterized. Despite a length of only 40 amino acids, PhoSL exclusively recognizes N‐glycans with α1,6‐linked fucose. Core fucosylation influences the intrinsic properties and bioactivities of mammalian N‐glycoproteins and its level is linked to various cancers. Thus, PhoSL serves as
Aurore Cabanettes, Lukas Perkams, Carolina Spies, Carlo Unverzagt, Annabelle Varrot   +4 more
openaire   +4 more sources

Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation

Antibodies, 2019
The biological activity of therapeutic antibodies is highly influenced by their glycosylation profile. A valuable method for increasing the cytotoxic efficacy of antibodies, which are used, for example, in cancer treatment, is the reduction of core ...
Martina Zimmermann, Janike Ehret, Harald Kolmar, Aline Zimmer   +3 more
doaj   +1 more source

The identification and characterization of novel N-glycan-based biomarkers in gastric cancer. [PDF]

PLoS ONE, 2013
BACKGROUND AND AIMS:To identify and validate N-glycan biomarkers in gastric cancer (GC) and to elucidate their underlying molecular mechanism of action. METHODS:In total, 347 individuals, including patients with GC (gastric cancer) or atrophic gastritis ...
Long Liu, Bing Yan, Junlong Huang, Qunhao Gu, Lina Wang, Meng Fang, Jianpeng Jiao, Xiaoqiang Yue   +7 more
doaj   +1 more source