Results 41 to 50 of about 6,346 (81)

Double knockdown of α1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

BMC Biotechnology, 2007
Background Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans in vivo ...
Shitara Kenya, Iida Shigeru, Wakitani Masako, Inoue Miho, Mori Katsuhiro, Imai-Nishiya Harue, Satoh Mitsuo   +6 more
doaj   +1 more source

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +1 more source

Identification of immune subsets with distinct lectin binding signatures using multi-parameter flow cytometry: correlations with disease activity in systemic lupus erythematosus

Frontiers in Immunology
ObjectivesCell surface glycosylation can influence protein-protein interactions with particular relevance to changes in core fucosylation and terminal sialylation.
Enikő Szabó, Enikő Szabó, Anna Faragó, Anna Faragó, Gergely Bodor, Nikolett Gémes, Nikolett Gémes, László G. Puskás, László G. Puskás, László Kovács, Gábor J. Szebeni, Gábor J. Szebeni, Gábor J. Szebeni, Gábor J. Szebeni   +13 more
doaj   +1 more source

Core fucosylation of IL-2RB is required for natural killer cell homeostasis

Cell Reports
Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R).
Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington   +14 more
doaj   +1 more source

Therapy-induced remodeling of IgG and plasma N-glycans in breast cancer

BMC Cancer
Background Protein N-glycosylation plays a key role in cancer biology and may offer insights into tumor behavior and treatment response. This study investigated changes in N-glycosylation of immunoglobulin G (IgG) and total plasma proteins in patients ...
Martina Maričić Vrban, Barbara Radovani Trbojević, David Visentin, Katarina Ramljak, Iva Kirac, Mihaela Gaće, Ivan Milas, Gordan Lauc, Dragan Primorac, Ivan Gudelj   +9 more
doaj   +1 more source

Core fucosylation and its roles in gastrointestinal glycoimmunology. [PDF]

World J Gastrointest Oncol, 2023
Zhang NZ, Zhao LF, Zhang Q, Fang H, Song WL, Li WZ, Ge YS, Gao P.   +7 more
europepmc   +1 more source

Fucosylation in cancer and its role in anti-tumor immunity

European Journal of Cell Biology
Fucose-containing glycans are central regulators of cell-surface biology, influencing receptor signaling, cell adhesion, immune recognition, and tissue organization.
Alessia G. Liner, Heinz Läubli
doaj   +1 more source

Suppressing α-1,6-Fucosyltransferase With a Novel Small Molecule Inhibitor Ameliorates Inflammation in Murine T-Cell–Mediated Colitis Models

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Inflammatory bowel disease involves intractable intestinal inflammation often refractory to current pharmacotherapies. We investigated the therapeutic potential of a novel, orally available inhibitor targeting α -1,6-fucosyltransferase—
Akiko Asakura, Shinichiro Shinzaki, Yoshiyuki Manabe, Koki Hizume, Yuri Tsujii, Taku Tashiro, Takahiro Amano, Mizuki Tani, Yuriko Otake-Kasamoto, Takeo Yoshihara, Ryotaro Uema, Yoshiki Tsujii, Hideki Iijima, Yoshihiro Kamada, Daisuke Okuzaki, Daisuke Motooka, Tomohiko Fukuda, Takashi Kudo, Satoru Takahashi, Jianguo Gu, Eiji Miyoshi, Koichi Fukase, Yoshito Hayashi, Tetsuo Takehara   +23 more
doaj   +1 more source

FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. [PDF]

Aging Dis, 2023
Zhang W, Lin W, Zeng X, Zhang M, Chen Q, Tang Y, Sun J, Liang B, Zha L, Yu Z.   +9 more
europepmc   +1 more source

A high-resolution N-glycoproteome landscape of aging mouse ovary

Redox Biology
Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of the most important protein modifications has been especially unexplored in this context.
Yongqi Wu, Zhida Zhang, Yongchao Xu, Yingjie Zhang, Lin Chen, Yiwen Zhang, Ke Hou, Muyao Yang, Zhehui Jin, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
doaj   +1 more source