Results 21 to 30 of about 6,346 (81)

Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. [PDF]

PLoS ONE, 2010
We previously reported increased levels of protein-linked fucosylation with the development of liver cancer and identified many of the proteins containing the altered glycan structures. One such protein is alpha-1-antitrypsin (A1AT).
Mary Ann Comunale, Lucy Rodemich-Betesh, Julie Hafner, Mengjun Wang, Pamela Norton, Adrian M Di Bisceglie, Timothy Block, Anand Mehta   +7 more
doaj   +1 more source

Loss of core fucosylation suppressed the humoral immune response in Salmonella typhimurium infected mice

Journal of Microbiology, Immunology and Infection, 2021
Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid, Nianzhu Zhang, Hui Fang, Jianguo Gu, Ming Li, Wenzhe Li   +5 more
doaj   +1 more source

Targeting Post-Translational Modifications to Improve Combinatorial Therapies in Breast Cancer: The Role of Fucosylation

Cells, 2023
Various tumors rely on post-translational modifications (PTMs) to promote invasiveness and angiogenesis and to reprogram cellular energetics to abate anti-cancer immunity.
Gabriele Antonarelli, Valentina Pieri, Francesca Maria Porta, Nicola Fusco, Gaetano Finocchiaro, Giuseppe Curigliano, Carmen Criscitiello   +6 more
doaj   +1 more source

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +1 more source

Decreased core-fucosylation contributes to malignancy in gastric cancer. [PDF]

PLoS ONE, 2014
The object of the study is to identify N-glycan profiling changes associated with gastric cancer and explore the impact of core-fucosylation on biological behaviors of human gastric cancer cells.
Yun-Peng Zhao, Xin-Yun Xu, Meng Fang, Hao Wang, Qing You, Chang-Hong Yi, Jun Ji, Xing Gu, Ping-Ting Zhou, Cheng Cheng, Chun-Fang Gao   +10 more
doaj   +1 more source

Increased levels of acidic free-N-glycans, including multi-antennary and fucosylated structures, in the urine of cancer patients

PLoS ONE, 2022
We recently reported increased levels of urinary free-glycans in some cancer patients. Here, we focused on cancer related alterations in the levels of high molecular weight free-glycans.
Ken Hanzawa, Miki Tanaka-Okamoto, Hiroko Murakami, Noriko Suzuki, Mikio Mukai, Hidenori Takahashi, Takeshi Omori, Kenji Ikezawa, Kazuyoshi Ohkawa, Masayuki Ohue, Shunji Natsuka, Yasuhide Miyamoto   +11 more
doaj   +3 more sources

A Matrix-Assisted Laser Desorption/Ionization—Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated N-Glycans in Human Plasma

Frontiers in Chemistry, 2020
Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) have been associated with several diseases ranging from diabetes to various forms of cancer. However, it is challenging to address this important part of the
Osmond D. Rebello, Osmond D. Rebello, Simone Nicolardi, Guinevere S. M. Lageveen-Kammeijer, Jan Nouta, Richard A. Gardner, Wilma E. Mesker, Rob A. E. M. Tollenaar, Daniel I. R. Spencer, Manfred Wuhrer, David Falck   +10 more
doaj   +1 more source

Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]

PeerJ, 2021
Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu, Tianye Lin, Pan Kang, Zhikun Zhuang, Haibin Wang, Wei He, Qiushi Wei, Ziqi Li   +7 more
doaj   +2 more sources

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Cell Reports, 2017
Summary: Programmed cell death 1 (PD-1) is highly expressed on exhausted T cells and inhibits T cell activation. Antibodies that block the interaction between PD-1 and its ligand prevent this inhibitory signal and reverse T cell dysfunction, providing ...
Masahiro Okada, Shunsuke Chikuma, Taisuke Kondo, Sana Hibino, Hiroaki Machiyama, Tadashi Yokosuka, Miyako Nakano, Akihiko Yoshimura   +7 more
doaj   +1 more source