Results 31 to 40 of about 6,100 (143)
Multi-targeted therapy resistance via drug-induced secretome fucosylation
eLife, 2023 Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive.
Mark Borris D Aldonza +19 more
doaj +1 more source
Journal of Microbiology, Immunology and Infection, 2021 Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid +5 more
doaj +1 more source
Cells, 2023 Various tumors rely on post-translational modifications (PTMs) to promote invasiveness and angiogenesis and to reprogram cellular energetics to abate anti-cancer immunity.
Gabriele Antonarelli +6 more
doaj +1 more source
Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]
PLoS ONE, 2013 Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi +3 more
doaj +1 more source
Synthesis of a fucosylated and a non-fucosylated core structure of xylose-containing carbohydrate chains from N-glycoproteins [PDF]
Carbohydrate Research, 1994 The synthesis is reported of methyl 2-acetamido-4-O-[2-acetamido-2-deoxy-O-(3,6-di-O-alpha-D- mannopyranosyl-2-O-beta-D-xylopyranosyl-beta-D-mannopyranosyl)-beta-D- glucopyranosyl]-2-deoxy-beta-D-glucopyranoside (4) and methyl 2-acetamido-4-O-[2-acetamido-2-deoxy-4-O- (3,6-di-O-alpha-D- mannopyranosyl-2-O-beta-D-xylopyranosyl-beta-D-mannopyranosyl ...
Vliegenthart, J.F.G. +4 more
openaire +3 more sources
Quantitative analysis of core fucosylation of serum proteins in liver diseases by LC-MS-MRM. [PDF]
J Proteomics, 2018 Ma J +4 more
europepmc +2 more sources
PLoS ONE, 2022 We recently reported increased levels of urinary free-glycans in some cancer patients. Here, we focused on cancer related alterations in the levels of high molecular weight free-glycans.
Ken Hanzawa +11 more
doaj +3 more sources
Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]
PeerJ, 2021 Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu +7 more
doaj +2 more sources
A Strategy for Precise and Large Scale Identification of Core Fucosylated Glycoproteins [PDF]
Molecular & Cellular Proteomics, 2009 Core fucosylation (CF) patterns of some glycoproteins are more sensitive and specific than evaluation of their total respective protein levels for diagnosis of many diseases, such as cancers. Global profiling and quantitative characterization of CF glycoproteins may reveal potent biomarkers for clinical applications.
Wei, Jia +17 more
openaire +2 more sources
Frontiers in Chemistry, 2020 Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) have been associated with several diseases ranging from diabetes to various forms of cancer. However, it is challenging to address this important part of the
Osmond D. Rebello +10 more
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