Results 31 to 40 of about 6,346 (81)

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +1 more source

Impact of Acetylated and Non-Acetylated Fucose Analogues on IgG Glycosylation

Antibodies, 2019
The biological activity of therapeutic antibodies is highly influenced by their glycosylation profile. A valuable method for increasing the cytotoxic efficacy of antibodies, which are used, for example, in cancer treatment, is the reduction of core ...
Martina Zimmermann, Janike Ehret, Harald Kolmar, Aline Zimmer   +3 more
doaj   +1 more source

The identification and characterization of novel N-glycan-based biomarkers in gastric cancer. [PDF]

PLoS ONE, 2013
BACKGROUND AND AIMS:To identify and validate N-glycan biomarkers in gastric cancer (GC) and to elucidate their underlying molecular mechanism of action. METHODS:In total, 347 individuals, including patients with GC (gastric cancer) or atrophic gastritis ...
Long Liu, Bing Yan, Junlong Huang, Qunhao Gu, Lina Wang, Meng Fang, Jianpeng Jiao, Xiaoqiang Yue   +7 more
doaj   +1 more source

Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa

Scientific Reports, 2017
Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins.
Yoshitake Sakae, Tadashi Satoh, Hirokazu Yagi, Saeko Yanaka, Takumi Yamaguchi, Yuya Isoda, Shigeru Iida, Yuko Okamoto, Koichi Kato   +8 more
doaj   +1 more source

IgG1-Dominant Antibody Response Induced by Recombinant Trimeric SARS-CoV-2 Spike Protein with PIKA Adjuvant

Vaccines, 2023
Recombinant trimeric SARS-CoV-2 Spike protein with PIKA (polyI:C) adjuvant induces potent and durable neutralizing antibodies that protect against multiple SARS-CoV-2 variants. The immunoglobulin subclasses of viral-specific antibodies remain unknown, as
Jingxia Wang, Xinjia Mai, Yu He, Chenxi Zhu, Dapeng Zhou   +4 more
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The Dual Role and Clinical Potential of Core Fucosylation in Liver Diseases

Shengwu huaxue yu shengwu wuli jinzhan
Core fucosylation, catalyzed exclusively by fucosyltransferase 8 (FUT8), is an evolutionarily conserved post-translational modification that has emerged as a central regulatory hub linking liver homeostasis, chronic disease progression, and malignant ...
LEI Zi-Han, XU Hui-Min, ZHAO De-Zhi, GUO Yong-Hong, DU Hao-Qi   +4 more
doaj   +1 more source

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Nature Communications, 2020
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García, Laura Ceballos-Laita, Sonia Serna, Raik Artschwager, Niels C. Reichardt, Francisco Corzana, Ramon Hurtado-Guerrero   +6 more
doaj   +1 more source

A machine learning model for site-specific classification of N-glycoprotein fucosylation using tandem mass spectrometry and deep neural network

Journal of Analytical Science and Technology
Protein fucosylation is a biologically significant post-translational modification that modulates protein stability, receptor signaling, and immune function.
Mina Park, Catia Mota, Heeyoun Hwang
doaj   +1 more source

FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

Breast Cancer Research, 2017
Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as ...
Cheng-Fen Tu, Meng-Ying Wu, Yuh-Charn Lin, Reiji Kannagi, Ruey-Bing Yang   +4 more
doaj   +1 more source

Synergistic Effect and Mechanism of FUT8 Inhibitor 2FF With DOX for Cancer Treatment

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveChemotherapy is one of the important therapeutic approaches for cancer treatment. However, the emergence of multidrug resistance and side effects significantly limit its application.
XIE Zhi-Dong, ZHANG Xiao-Lian
doaj   +1 more source