Results 1 to 10 of about 3,642 (124)

CircFut8 Suppresses Bladder Cancer by Modulating SRSF9-Dependent Pre-mRNA Splicing. [PDF]

J Gene Med
This schematic illustrates the mechanism by which circFut8 suppresses bladder cancer progression. Under high circFut8 levels, circFut8 competitively binds the splicing factor SRSF9, reducing SRSF9's association with FUT8 pre‐mRNA. This promotes exon 3 skipping, leading to increased production of the FUT8‐4 splice variant, which correlates with reduced ...
Yang W, Yao L, Wan L, Zhuang C.
europepmc   +2 more sources

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses. [PDF]

PLoS Pathogens
Understanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun, Yixin Xiang, Yichen Yang, Yubei Tan, Zhelin Su, Zhen Fu, Yanan Fu, Shengsong Xie, Guiqing Peng   +8 more
doaj   +2 more sources

Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling [PDF]

International Dental Journal
Background: Chronic inflammation in periodontitis is linked to aberrant glycosylation, yet the molecular mechanisms and therapeutic potential of the core fucosyltransferase Fut8 remain undefined.
Jiahao Lin, Yongxi Luo, Lu Chen, Cheng Zeng, Lu Wang, Xinmiao Luo, Li Zeng, Huiyong Xu, Zhao Chen   +8 more
doaj   +2 more sources

Glycoengineered Recombinant Alpha1-Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma-Derived Protein. [PDF]

Biotechnol Bioeng
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Rocamora F, Hsieh CL, Schoffelen S, Arnsdorf J, Toth EA, Yunus AS, Cleveland TE, Bjørn SP, Wu MYM, McElvaney NG, Voldborg BGR, Fuerst TR, Lewis NE.   +12 more
europepmc   +2 more sources

FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression [PDF]

Cell Death Discovery
Clear cell renal cell carcinoma (ccRCC) is characterized by the loss of the von Hippel–Lindau (VHL) gene, leading to constitutive activation of hypoxia-inducible transcription factors (HIFs) and metabolic reprogramming toward aerobic glycolysis. Although
Zikai Guo, Hongxiao Jiang, Xu Wang, Ke Xuan, Huidong Zhong, Chengxi Liu, Mengkai Zhang, Zhichao Li, Weiren Huang, Yangyang Sun   +9 more
doaj   +2 more sources

Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification. [PDF]

PLoS Genetics
BackgroundColorectal cancer (CRC) is a prevalent malignancy with significant mortality rates globally. Understanding the genetic and molecular mechanisms underlying CRC development is crucial for improving therapeutic strategies.MethodIn this study, we ...
Yu Zhang, Xu Han, Yichun Yang, Jiayan Ren, Zixi Zhang, Yanmin Zhang, Qi Su, Dake Chu   +7 more
doaj   +2 more sources

Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation

Frontiers in Chemistry, 2021
The α1,6-fucosyltransferase (encoded by FUT8 gene) is the key enzyme transferring fucose to the innermost GlcNAc residue on an N-glycan through an α-1,6 linkage in the mammalian cells.
Ganglong Yang, Hui Zhang, Michael Betenbaugh   +2 more
exaly   +3 more sources

Hepatitis C Virus-Induced FUT8 Causes 5-FU Drug Resistance in Human Hepatoma Huh7.5.1 Cells

Viruses, 2019
Hepatitis C virus (HCV) is a major cause of human chronic liver disease and hepatocellular carcinoma. Our recent studies showed that α1,6-fucosyltransferase (FUT8), a key glycosyltransferase, was the most up-regulated glycosyltransferase after the ...
Xiao-Lian Zhang, Qiu Pan
exaly   +3 more sources

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors [PDF]

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +2 more sources

Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]

Nature Communications
Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang, Dongyang He, Mengyu Ke, Jinhua Qin, Guang Yang, Biao Yu, Jing Wang, Pengfei Fang   +7 more
doaj   +2 more sources