Results 1 to 10 of about 616 (125)
L-Fucose treatment of FUT8-CDG
Molecular Genetics and Metabolism Reports, 2020 FUT8-CDG is a severe multisystem disorder caused by mutations in FUT8, encoding the α-1,6-fucosyltransferase. We report on dizygotic twins with FUT8-CDG presenting with dysmorphisms, failure to thrive, and respiratory abnormalities.
Julien H. Park +10 more
doaj +5 more sources
Immunity, Inflammation and Disease, 2022 Background α‐1,6 Fucosyltransferase (FUT8) appears to play an essential role in the pathogenesis of renal fibrosis. However, it remained unknown whether FUT8 also contributed to renal fibrosis in immunoglobulin A nephropathy (IgAN). In the present study,
Hongli Lin, Xia-Nan Guo, Xiang-Ning Du
exaly +3 more sources
Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]
PLoS ONE, 2013 Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi +3 more
doaj +6 more sources
Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation [PDF]
Frontiers in Chemistry, 2021 The α1,6-fucosyltransferase (encoded by FUT8 gene) is the key enzyme transferring fucose to the innermost GlcNAc residue on an N-glycan through an α-1,6 linkage in the mammalian cells.
Ganglong Yang +2 more
exaly +5 more sources
Diagnosis and prognosis of serum Fut8 for epilepsy and refractory epilepsy in children
PLoS ONE, 2023 With adequate serum concentration of antiepileptic drugs, the epilepsy symptoms in many patients still cannot be controlled well. The alteration of glycosyltransferase has obvious influence on the pathogenesis of epilepsy.
Yunxiu Huang, Zhou Zhang, Linmu Chen
doaj +5 more sources
Frontiers in Oncology, 2021 Melanoma is the major lethal skin malignancy. However, the critical molecular drivers governing melanoma progression and prognosis are still not clear. By analyzing The Cancer Genome Atlas (TCGA) data, we identified FUT8-AS1 as a prognosis-related long ...
Xiangjun Chen
exaly +3 more sources
Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]
PeerJ, 2021 Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu +7 more
doaj +2 more sources
Journal of Microbiology, Immunology and Infection, 2021 Background: The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses ...
Danish Zahid +5 more
doaj +1 more source
Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. [PDF]
PLoS ONE, 2016 The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed
Yutaka Okagawa +12 more
doaj +1 more source
FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation
Breast Cancer Research, 2017 Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as ...
Cheng-Fen Tu +4 more
doaj +1 more source