Results 41 to 50 of about 4,088 (175)

Table4_Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation.XLSX

, 2021
The α1,6-fucosyltransferase (encoded by FUT8 gene) is the key enzyme transferring fucose to the innermost GlcNAc residue on an N-glycan through an α-1,6 linkage in the mammalian cells.
Michael J. Betenbaugh (104692), Qiong Wang (117288), Lijun Chen (313408), Ganglong Yang (778465), Hui Zhang (7197)   +4 more
core   +1 more source

Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota

Frontiers in Microbiology, 2020
The fucosylated carbohydrate moieties on intestinal epithelial cells (IECs) are involved in the creation of an environmental niche for commensal and pathogenic bacteria. Core fucosylation catalyzed by fucosyltransferase 8 (Fut8) is the major fucosylation
Sijia Hao, Qingjie Fan, Yaqiang Bai, Hui Fang, Jiaorui Zhou, Tomohiko Fukuda, Jianguo Gu, Ming Li, Wenzhe Li   +8 more
doaj   +1 more source

Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases [PDF]

, 2020
Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins.
Wang, Lai-Xi, Zong, Guanghui, Ramiah, Annapoorani, Moremen, Kelley W, Boruah, Bhargavi M, Bosman, Gerlof P, Wood, Zachary A, Kadirvelraj, Renuka, Yang, Jeong-Yeh, Li, Chao, Liu, Lin, Boons, Geert-Jan   +11 more
core   +3 more sources

Blocking Posttranslational Core Fucosylation Ameliorates Rat Peritoneal Mesothelial Cell Epithelial-Mesenchymal Transition

Chinese Medical Journal, 2017
Background: Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor
Long-Kai Li, Nan Wang, Wei-Dong Wang, Xiang-Ning Du, Xin-Yu Wen, Ling-Yu Wang, Yi-Yao Deng, Da-Peng Wang, Hong-Li Lin   +8 more
doaj   +1 more source

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Nature Communications, 2020
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García, Laura Ceballos-Laita, Sonia Serna, Raik Artschwager, Niels C. Reichardt, Francisco Corzana, Ramon Hurtado-Guerrero   +6 more
doaj   +1 more source

N6‐methyladenosine‐modified circFUT8 competitively interacts with YTHDF2 and miR‐186‐5p to stabilize FUT8 mRNA to promote malignant progression in lung adenocarcinoma

Thoracic Cancer, 2023
Background Lung cancer is the leading cause of cancer related to mortality worldwide, and the main pathological type is lung adenocarcinoma (LUAD). Circular RNAs (circRNAs) have been reported to be modified by N6‐methyladenosine (m6A), which is involved ...
Gaochao Dong, Yingkuan Liang, Bing Chen, Te Zhang, Hui Wang, Yuzhong Chen, Yijian Zhang, Feng Jiang, Yaping Wang   +8 more
doaj   +1 more source

α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

Cells, 2022
Glycosylation is an important mechanism regulating various biological processes, including intercellular signaling and adhesion. α-1,6-fucosyltransferase (Fut8) belongs to a family of enzymes that determine the terminal structure of glycans.
Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa   +7 more
doaj   +1 more source

Correlations among serum alpha-(1,6)-fucosyltransferase and early symptoms associated with Parkinson's disease: A cross-sectional retrospective study

Brain Research Bulletin
Alpha-(1,6)-fucosyltransferase (FUT8) has been found to play a role in modulating the central immune system and inflammatory responses. Limited studies have assessed the correlations between serum FUT8 levels and various non-motor symptoms associated ...
Qi-rong Wang, Xue Yu, Yang Li, Ming-zhen Zhu   +3 more
doaj   +1 more source

Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer.

PLoS ONE, 2018
The expression of fucosyltransferase 8, an enzyme responsible for core fucosylation encoded by FUT8, influences tumor biology and correlates with patient prognosis in several solid cancers.
Masaru Noda, Hirokazu Okayama, Yasuhide Kofunato, Shun Chida, Katsuharu Saito, Takeshi Tada, Mai Ashizawa, Takahiro Nakajima, Keita Aoto, Tomohiro Kikuchi, Wataru Sakamoto, Hisahito Endo, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono   +16 more
doaj   +1 more source

Table1_Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation.XLSX

, 2021
The α1,6-fucosyltransferase (encoded by FUT8 gene) is the key enzyme transferring fucose to the innermost GlcNAc residue on an N-glycan through an α-1,6 linkage in the mammalian cells.
Michael J. Betenbaugh (104692), Qiong Wang (117288), Lijun Chen (313408), Ganglong Yang (778465), Hui Zhang (7197)   +4 more
core   +1 more source