Results 41 to 50 of about 616 (125)

p53 and FUT8 regulate the introduction of Fuc-Lip-Cy5.5 into HCC cells.

, 2016
(A) Expression levels of p53 and FUT8 in HCC cells were examined by western blot. (B) Quantification of AFP-L3 values. (C) Determination of the introduction of Fuc-Lip-Cy5.5 into HCC cells. After siRNA transfection, HepG2 and JHH7 cells were exposed to 1
Hajime Nakamura (3428984), Yusuke Kamihara (3214998), Naotaka Hayasaka (3560810), Makoto Usami (757009), Koji Miyanishi (151762), Kazuyuki Murase (151747), Yutaka Okagawa (3560807), Junji Kato (151778), Takahiro Osuga (151758), Masayoshi Kobune (151774), Kohichi Takada (151767), Shohei Kikuchi (832677), Yohei Arihara (3560813)   +12 more
core   +1 more source

EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses

Nature Communications
Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis.
Qiu Pan, Yan Xie, Ying Zhang, Xinqi Guo, Jing Wang, Min Liu, Xiao-Lian Zhang   +6 more
doaj   +1 more source

Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity

Frontiers in Immunology, 2022
Most of the membrane molecules involved in immune response are glycosylated. N-glycans linked to asparagine (Asn) of immune molecules contribute to the protein conformation, surface expression, stability, and antigenicity.
Yuhan Sun, Yuhan Sun, Xueying Li, Tiantong Wang, Wenzhe Li   +4 more
doaj   +1 more source

Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling

International Dental Journal
Background: Chronic inflammation in periodontitis is linked to aberrant glycosylation, yet the molecular mechanisms and therapeutic potential of the core fucosyltransferase Fut8 remain undefined.
Jiahao Lin, Yongxi Luo, Lu Chen, Cheng Zeng, Lu Wang, Xinmiao Luo, Li Zeng, Huiyong Xu, Zhao Chen   +8 more
doaj   +1 more source

Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

Frontiers in Immunology, 2018
CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang, Shanshan Mao, Shijie Sun, Ming Li, Zhi Li, Rui Yu, Tonghui Ma, Jianguo Gu, Jianing Zhang, Naoyuki Taniguchi, Wenzhe Li   +10 more
doaj   +1 more source

Correlations between the serum Fut8 with clinical characteristics in epilepsy and refractory epilepsy group.

, 2023
Correlations between the serum Fut8 with clinical characteristics in epilepsy and refractory epilepsy group.
Zhou Zhang (197948), Yunxiu Huang (15285530), Linmu Chen (14439559)   +2 more
core   +1 more source

Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification.

PLoS Genetics
BackgroundColorectal cancer (CRC) is a prevalent malignancy with significant mortality rates globally. Understanding the genetic and molecular mechanisms underlying CRC development is crucial for improving therapeutic strategies.MethodIn this study, we ...
Yu Zhang, Xu Han, Yichun Yang, Jiayan Ren, Zixi Zhang, Yanmin Zhang, Qi Su, Dake Chu   +7 more
doaj   +1 more source

Fucosyltransferase 8 is associated with post-thrombotic vein wall fibrosis and macrophage profibrotic signaling

JVS - Vascular Science
Objective: To investigate the role of fucosyltransferase 8 (FUT8) in post-thrombotic (PT) vein wall fibrosis and to clarify its association with focal adhesion kinase (FAK)/extracellular signal-regulated kinase (ERK) signaling in macrophage-mediated ...
Guodong Du, MD, Yu Jin, MD, Hongji Pu, PhD, Xin Wang, MD, Xinrui Yang, PhD, Xinwu Lu, MD, PhD, Ruihua Wang, MD, PhD   +6 more
doaj   +1 more source

Genomic structure and promoter analysis of the human  1,6-fucosyltransferase gene (FUT8) [PDF]

Glycobiology, 2000
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase (alpha1,6FucT) catalyzes the transfer of a fucosyl moiety from GDP-fucose to the asparagine-linked GlcNAc residue of complex N-glycans via alpha1,6-linkage. We have cloned the genomic DNA which encodes the human alpha1,6FucT gene ( FUT8 ) and analyzed its structure.
Y, Yamaguchi, Y, Ikeda, T, Takahashi, H, Ihara, T, Tanaka, C, Sasho, N, Uozumi, S, Yanagidani, S, Inoue, J, Fujii, N, Taniguchi   +10 more
openaire   +2 more sources

FUT8-mediated core fucosylation of receptor APN drives entry of multiple alphacoronaviruses.

PLoS Pathogens
Understanding the interaction mechanisms between coronaviruses (CoVs) and their hosts is crucial for understanding the viral replication cycle and identifying novel antiviral targets. In this study, we found alpha-(1,6)-fucosyltransferase (FUT8), via its
Limeng Sun, Yixin Xiang, Yichen Yang, Yubei Tan, Zhelin Su, Zhen Fu, Yanan Fu, Shengsong Xie, Guiqing Peng   +8 more
doaj   +1 more source