Results 1 to 10 of about 7,198,263 (194)

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS One, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Bernardi C, Soffientini U, Piacente F, Tonetti MG.   +3 more
europepmc   +7 more sources

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response. [PDF]

PLoS One, 2023
GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data.
Kyunai YM, Sakamoto M, Koreishi M, Tsujino Y, Satoh A.   +4 more
europepmc   +6 more sources

Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts. [PDF]

PeerJ, 2021
Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Wu Z, Lin T, Kang P, Zhuang Z, Wang H, He W, Wei Q, Li Z.   +7 more
europepmc   +5 more sources

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer. [PDF]

Biochem Biophys Rep, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Shimoyama H, Shibata TK, Ito M, Oda T, Itoh T, Mukai M, Matsuya-Ogawa M, Adachi M, Murakami H, Nakayama T, Sugihara K, Itoh H, Suzuki T, Kanayama N.   +13 more
europepmc   +4 more sources

Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression. [PDF]

Nat Commun
Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiang J, He D, Ke M, Qin J, Yang G, Yu B, Wang J, Fang P.   +7 more
europepmc   +4 more sources

Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. [PDF]

PLoS One, 2016
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed
Okagawa Y, Takada K, Arihara Y, Kikuchi S, Osuga T, Nakamura H, Kamihara Y, Hayasaka N, Usami M, Murase K, Miyanishi K, Kobune M, Kato J.   +12 more
europepmc   +2 more sources

Fucosyltransferase 8-Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1-TNF Signaling Axis to Promote Lung Cancer Progression. [PDF]

Thorac Cancer
Background Lung cancer, representing a predominant form of pulmonary malignancy, demonstrates significant disease burden and poor clinical outcomes. Circular RNAs (circRNAs) have emerged as critical regulators in various cancers, including lung cancer ...
Ren Y, Shen Y, Wu Q, Zhang P, Wang L, Li F, Shen Y.   +6 more
europepmc   +2 more sources

POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma. [PDF]

Brain Behav
ABSTRACT Objective Protein O‐fucosyltransferase 1 (POFUT1) has been implicated in several malignancies, but its functional and prognostic significance in glioma remains insufficiently defined. This study evaluated whether POFUT1 expression is associated with glioma progression, patient outcome, and PI3K/AKT pathway activity.
Yang K, Ju C, Wang Y, Guo A, Yang X, Mi Y, Su Y, Wang C, Ji H.   +8 more
europepmc   +2 more sources

Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity

Molecular Therapy: Methods & Clinical Development, 2021
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of
James M. Termini, José M. Martinez-Navio, Guangping Gao, Sebastian P. Fuchs, Ronald C. Desrosiers   +4 more
doaj   +1 more source

IgG1-Dominant Antibody Response Induced by Recombinant Trimeric SARS-CoV-2 Spike Protein with PIKA Adjuvant

Vaccines, 2023
Recombinant trimeric SARS-CoV-2 Spike protein with PIKA (polyI:C) adjuvant induces potent and durable neutralizing antibodies that protect against multiple SARS-CoV-2 variants. The immunoglobulin subclasses of viral-specific antibodies remain unknown, as
Jingxia Wang, Xinjia Mai, Yu He, Chenxi Zhu, Dapeng Zhou   +4 more
doaj   +1 more source