Results 1 to 10 of about 74,907,945 (195)

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +7 more sources

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response. [PDF]

PLoS ONE, 2023
GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data.
Yuki M Kyunai, Mika Sakamoto, Mayuko Koreishi, Yoshio Tsujino, Ayano Satoh   +4 more
doaj   +6 more sources

Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]

PeerJ, 2021
Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu, Tianye Lin, Pan Kang, Zhikun Zhuang, Haibin Wang, Wei He, Qiushi Wei, Ziqi Li   +7 more
doaj   +5 more sources

Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]

Nature Communications
Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang, Dongyang He, Mengyu Ke, Jinhua Qin, Guang Yang, Biao Yu, Jing Wang, Pengfei Fang   +7 more
doaj   +4 more sources

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer [PDF]

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +4 more sources

Fucosyltransferase 8 is associated with post-thrombotic vein wall fibrosis and macrophage profibrotic signaling [PDF]

JVS - Vascular Science
Objective: To investigate the role of fucosyltransferase 8 (FUT8) in post-thrombotic (PT) vein wall fibrosis and to clarify its association with focal adhesion kinase (FAK)/extracellular signal-regulated kinase (ERK) signaling in macrophage-mediated ...
Guodong Du, MD, Yu Jin, MD, Hongji Pu, PhD, Xin Wang, MD, Xinrui Yang, PhD, Xinwu Lu, MD, PhD, Ruihua Wang, MD, PhD   +6 more
doaj   +3 more sources

Fucosyltransferase 8 is Overexpressed and Influences Clinical Outcomes in Lung Adenocarcinoma Patients [PDF]

Pathology and Oncology Research, 2022
Background: Lung adenocarcinoma (LUAD), the most prevalent type of lung cancer, is often metastatic and has a poor prognosis. Recent studies have demonstrated an important role for fucosyltransferase 8 (FUT8) in carcinogenesis and cancer progression.Methods: A meta-analysis with 15 eligible datasets from Gene Expression Omnibus (GEO) was performed to ...
Liang, Yiqian, Wang, Ting, Gao, Rui, Jia, Xi, Ji, Ting, Shi, Puyu, Xue, Jianjun, Yang, Aimin, Chen, Mingwei, Han, Peng   +9 more
openaire   +3 more sources

Structural basis of substrate recognition and catalysis by fucosyltransferase 8 [PDF]

Journal of Biological Chemistry, 2020
Abstract Fucosylation of the inner-most N-acetyl-glucosamine (GlcNAc) of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can have a dramatic impact on the activity and half-life of glycoproteins.
Järvå, Michael A., Dramicanin, Marija, Lingford, James P., Mao, Runyu, John, Alan, Jarman, Kate, Grinter, Rhys W., Goddard-Borger, Ethan D.   +7 more
openaire   +3 more sources

Fucosyltransferase 3 and 8 promote the metastatic capacity of cancer stem-like cells via CD15s and E-cadherin in esophageal cancer [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Esophageal cancer stem cells (ECSCs) have been identified as the subset of cells within esophageal squamous cell carcinoma that possess tumorigenic, invasive, and metastatic properties.
Aliakbar Rostami Abookheili, Jahanbakhsh Asadi, Ayyoob Khosravi, Ali Gorji   +3 more
doaj   +3 more sources

O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis

Nature Communications
The phytohormone auxin plays a pivotal role in promoting fruit initiation and growth upon fertilization in flowering plants. Upregulation of auxin signaling by genetic mutations or exogenous auxin treatment can induce seedless fruit formation from ...
Yan Wang, Seamus Kelley, Rodolfo Zentella, Jianhong Hu, Hua Wei, Lei Wang, Jeffrey Shabanowitz, Donald F. Hunt, Tai-ping Sun   +8 more
doaj   +3 more sources